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  Liquid-crystal organization of liver tissue

Morales-Navarrete, H., Nonaka, H., Scholich, A., Segovia-Miranda, F., de Back, W., Meyer, K., et al. (2019). Liquid-crystal organization of liver tissue. eLife, 8: e44860. doi:10.7554/eLife.44860.

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 Creators:
Morales-Navarrete, Hernan1, Author
Nonaka, Hidenori1, Author
Scholich, Andre2, Author              
Segovia-Miranda, Fabian1, Author
de Back, Walter1, Author
Meyer, Kirstin1, Author
Bogorad, Roman L.1, Author
Koteliansky, Victor1, Author
Brusch, Lutz1, Author
Kalaidzidis, Yannis1, Author
Jülicher, Frank2, Author              
Friedrich, Benjamin M.1, Author
Zerial, Marino1, Author
Affiliations:
1external, ou_persistent22              
2Max Planck Institute for the Physics of Complex Systems, Max Planck Society, ou_2117288              

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 Abstract: Functional tissue architecture originates by self-assembly of distinct cell types, following tissue-specific rules of cell-cell interactions. In the liver, a structural model of the lobule was pioneered by Elias in 1949. This model, however, is in contrast with the apparent random 3D arrangement of hepatocytes. Since then, no significant progress has been made to derive the organizing principles of liver tissue. To solve this outstanding problem, we computationally reconstructed 3D tissue geometry from microscopy images of mouse liver tissue and analyzed it applying soft-condensed-matter-physics concepts. Surprisingly, analysis of the spatial organization of cell polarity revealed that hepatocytes are not randomly oriented but follow a long-range liquidcrystal order. This does not depend exclusively on hepatocytes receiving instructive signals by endothelial cells, since silencing Integrin-beta 1 disrupted both liquid-crystal order and organization of the sinusoidal network. Our results suggest that bi-directional communication between hepatocytes and sinusoids underlies the self-organization of liver tissue.

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 Dates: 2019-06-17
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000473398900001
DOI: 10.7554/eLife.44860
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Title: eLife
Source Genre: Journal
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: 8 Sequence Number: e44860 Start / End Page: - Identifier: ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X