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  The anti-protozoal drug pentamidine blocks KIR2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel.

de Boer, T. P., Nalos, L., Stary, A., Kok, B., Houtman, M. J. C., Antoons, G., et al. (2010). The anti-protozoal drug pentamidine blocks KIR2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel. British Journal of Pharmacology, 159(7), 1532-1541. Retrieved from http://www3.interscience.wiley.com/cgi-bin/fulltext/123301886/PDFSTART.

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587760.pdf (Publisher version), 745KB
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de Boer, T. P., Author
Nalos, L., Author
Stary, A.1, Author           
Kok, B., Author
Houtman, M. J. C., Author
Antoons, G., Author
van Feen, T. A. B., Author
Beekman, J. D. M., Author
de Groot, B. L.1, Author           
Opthof, T., Author
Rook, M. B., Author
Vos, M. A., Author
van der Heyden, M. A. G., Author
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1Research Group of Computational Biomolecular Dynamics, MPI for biophysical chemistry, Max Planck Society, ou_578573              

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Free keywords: inward rectifier current; /K1; KIR2.1; pentamidine; ECG; arrhythmia; molecular modelling
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 Dates: 2010-02-24
 Publication Status: Issued
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Title: British Journal of Pharmacology
Source Genre: Journal
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Pages: - Volume / Issue: 159 (7) Sequence Number: - Start / End Page: 1532 - 1541 Identifier: -