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Schlagwörter:
Serotonin; Gene structure; Alternative splicing; Mouse brain; Exon alignment
Zusammenfassung:
We have isolated the murine gene encoding the 5−HT3 receptor (5−HT3R), a member of the ligand−gated ion channels, that mediates a variety of physiological effects in central and peripheral neurons. DNA sequence analysis of the 5−HT3R gene revealed its organisation in 9 exons distributed over approximately 12 kbp of DNA. Alternative use ofexon 9 splice acceptor sites generated two 5−HT3R variants. The 5−HT3R gene, whose structure is closely related to neuronal and muscle AchRα genes, as demonstrated by four common splice junctions, was localised on human chromosome 11
