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  Elegant method to quantify chemical exchange processes for pH CEST imaging

Goerke, S., Windschuh, J., Zaiss, M., Meissner, J.-E., Ladd, M., & Bachert, P. (2017). Elegant method to quantify chemical exchange processes for pH CEST imaging. Poster presented at 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017), Honolulu, HI, USA.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0000-C4BF-C Version Permalink: https://hdl.handle.net/21.11116/0000-0000-F30C-1
Genre: Poster

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Goerke, S, Author
Windschuh, J, Author
Zaiss, M1, 2, Author           
Meissner, J-E, Author
Ladd, M, Author
Bachert, P, Author
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: A novel concentration-independent approach is presented to determine the pH-dependence of exchange rates employing a single CEST image of a set of model solutions at different pH. Not only the comparatively short acquisition time, but also the robustness against variations in relaxation parameters makes this modality an elegant way to determine exchange rates in vitro. The calibrated functions are required for accurate pH mapping in vivo using CEST, as well as for design of exogenous CEST contrast agents.

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 Dates: 2017-04-25
 Publication Status: Issued
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 Identifiers: BibTex Citekey: GoerkeWZMLB2017
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Title: 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017)
Place of Event: Honolulu, HI, USA
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Title: 25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2017)
Source Genre: Proceedings
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