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  Divergent Total Synthesis of the Antimitotic Agent Leiodermatolide

Willwacher, J., Kausch-Busies, N., & Fürstner, A. (2012). Divergent Total Synthesis of the Antimitotic Agent Leiodermatolide. Angewandte Chemie International Edition, 51(48), 12041-12046. doi:10.1002/anie.201206670.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-2562-1 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0028-300D-2
Genre: Journal Article

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[300]SI.pdf (Supplementary material), 8MB
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https://hdl.handle.net/11858/00-001M-0000-0028-300E-F
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Copyright Date:
2012
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Wiley-VCH, 69451 Weinheim, Germany
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 Creators:
Willwacher, Jens1, Author           
Kausch-Busies, Nina1, Author           
Fürstner, Alois1, Author           
Affiliations:
1Research Department Fürstner, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445584              

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Free keywords: alkyne metathesis; antitumor agents; natural products; structure eludication; total synthesis
 Abstract: Subtle but distinctive: The stereostructure of the biologically highly promising antimitotic agent leiodermatolide was uncertain. A short, efficient, and flexible total synthesis based on ring-closing alkyne metathesis as the key step has now solved the puzzle. Subtle differences in the 1H NMR spectra of the structure shown and the conceivable isomer proved invaluable for the assignment.

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Language(s): eng - English
 Dates: 2012-10-182012-11-26
 Publication Status: Issued
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/anie.201206670
 Degree: -

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Title: Angewandte Chemie International Edition
  Other : Angewandte Chemie International Edition in English
  Other : Angewandte Chemie - International Edition
  Abbreviation : Angew. Chem. Int. Ed.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: 6 Volume / Issue: 51 (48) Sequence Number: - Start / End Page: 12041 - 12046 Identifier: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/201310171