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  Evolutionary design of oscillatory genetic networks

Kobayashi, Y., Shibata, T., Kuramoto, Y., & Mikhailov, A. S. (2010). Evolutionary design of oscillatory genetic networks. European Physical Journal B, 76(1), 167-178. doi:10.1140/epjb/e2010-00200-9.

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 Creators:
Kobayashi, Yasuaki1, Author              
Shibata, Tatsuo, Author
Kuramoto, Yoshiki, Author
Mikhailov, Alexander S.1, Author              
Affiliations:
1Physical Chemistry, Fritz Haber Institute, Max Planck Society, ou_634546              

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Free keywords: 87.16.Yc Regulatory genetic and chemical networks; 87.18.Vf Systems biology; 89.75.Hc Networks and genealogical trees
 Abstract: The present study is devoted to the design and statistical investigations of dynamical gene expression networks. In our model problem, we aim to design genetic networks which would exhibit stable periodic oscillations with a prescribed temporal period. While no rational solution of this problem is available, we show that it can be effectively solved by running a computer evolution of the network models. In this process, structural rewiring mutations are applied to the networks with inhibitory interactions between genes, and the evolving networks are selected depending on whether, after a mutation, they closer approach the targeted dynamics. We show that, by using this method, networks with required oscillation periods, varying by up to three orders of magnitude, can be constructed by changing the architecture of regulatory connections between the genes. Statistical properties of designed networks, including motif distributions and Laplacian spectra, are considered.

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Language(s): eng - English
 Dates: 2010-06-29
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 463833
DOI: 10.1140/epjb/e2010-00200-9
 Degree: -

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Title: European Physical Journal B
  Alternative Title : Eur. Phys. J. B
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 76 (1) Sequence Number: - Start / End Page: 167 - 178 Identifier: -