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  Introducing a new recruitment approach to sample collection for genetic association studies in opioid dependence

Franke, P., Wendel, B., Knapp, M., Schwab, S. G., Neef, D., Maier, W., et al. (2003). Introducing a new recruitment approach to sample collection for genetic association studies in opioid dependence. European Psychiatry, 18(1), 18-22. doi:10.1016/S0924-9338(02)00005-6.

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Genre: Journal Article
Alternative Title : Eur. Psychiat.

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 Creators:
Franke, Petra, Author
Wendel, Birgit, Author
Knapp, Michael, Author
Schwab, Sybille G., Author
Neef, Daniela, Author
Maier, Wolfgang, Author
Wildenauer, Dieter B., Author
Hoehe, Margret R.1, Author              
Affiliations:
1Genetic Variation, Haplotypes, and Genetics of Complex Disease (Margret Hoehe), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479651              

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Free keywords: addiction, opioids, OPRM1, polyrnorphisin, case-control study
 Abstract: Objective: In a modified case–control association study we tested the assumption that two polymorphisms (A118G in exon 1 and IVS2+31 in intron 2) of the human -opioid receptor gene (OPRM1) confer susceptibility to opioid dependence. Methods: In contrast to classical case–control studies both groups, opioid dependent cases and non-opioid dependent controls were recruited from individuals who have had access to drugs including opioids and who had been sentenced for violation of the "Dangerous Drugs Act" in Germany. Results: For the two allelic variants of OPRM1 under study we did not find evidence for association with opioid dependence. Conclusions. – Despite absence of association we think that this recruitment approach introduced here, is useful since it putatively offers a more adequate matching for case–control association studies of opioid dependent individuals.

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Language(s): eng - English
 Dates: 2003-02
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 175352
ISI: 000181999600004
DOI: 10.1016/S0924-9338(02)00005-6
 Degree: -

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Title: European Psychiatry
  Alternative Title : Eur. Psychiat.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 18 (1) Sequence Number: - Start / End Page: 18 - 22 Identifier: ISSN: 0924-9338