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  Neuronal stability in medial frontal cortex sets individual variability in decision-making

Kurikawa, T., Haga, T., Handa, T., Harukuni, R., & Fukai, T. (2018). Neuronal stability in medial frontal cortex sets individual variability in decision-making. Nature Neuroscience, 21(12), 1764-1773. doi:10.1038/s41593-018-0263-5.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0004-40E4-2 Versions-Permalink: https://hdl.handle.net/21.11116/0000-0004-40E8-E
Genre: Zeitschriftenartikel

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https://www.nature.com/articles/s41593-018-0263-5 (Zusammenfassung)
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 Urheber:
Kurikawa, Tomoki1, Autor
Haga, Tatsuya1, Autor
Handa, Takashi1, Autor
Harukuni, Rie1, Autor
Fukai, Tomoki1, Autor
Affiliations:
1External Organizations, ou_persistent22              

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Schlagwörter: -
 Zusammenfassung: In the brain, decision making is instantiated in dedicated neural circuits. However, there is considerable individual variability in decision-making behavior, particularly under uncertainty. The origins of decision variability within these conserved neural circuits are not known. Here we demonstrate in the rat medial frontal cortex (MFC) that individual variability is a consequence of altered stability in neuronal populations. In a sensory-guided choice task, rats trained on familiar stimuli were exposed to unfamiliar stimuli, resulting in variable choice responses across individuals. We created a recurrent network model to examine the source of variability in MFC neurons, and found that the landscape of neural population trajectories explained choice variability across different unfamiliar stimuli. We experimentally confirmed model predictions showing that trial-by-trial variability in neuronal activity indexes the landscape and predicts individual variation. These results show that neural stability is a critical component of the MFC neural dynamics that underpins individual variation in decision-making.

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Sprache(n): eng - English
 Datum: 2018-12
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: ISI: 000451324700014
DOI: 10.1038/s41593-018-0263-5
 Art des Abschluß: -

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Titel: Nature Neuroscience
  Andere : Nat. Neurosci.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: New York, NY : Nature America Inc.
Seiten: - Band / Heft: 21 (12) Artikelnummer: - Start- / Endseite: 1764 - 1773 Identifikator: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931