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Abstract:
The large scale behavior of a population of cells that grow and interact through the concentration field of the chemicals they secrete is studied using dynamical renormalization group methods. The combination of the effective long-range chemotactic interaction and lack of number conservation leads to a rich variety of phase behavior in the system, which includes a sharp transition from a phase that has moderate (or controlled) growth and regulated chemical interactions to a phase with strong (or uncontrolled) growth and no chemical interactions. The transition point has nontrivial critical exponents. Our results might help shed light on the interplay between chemical signaling and growth in tissues and colonies, and in particular on the challenging problem of cancer metastasis. © 2015 American Physical Society.
