非表示:
キーワード:
addiction, opioids, OPRM1, polyrnorphisin, case-control study
要旨:
Objective:
In a modified case–control association study we tested the assumption that two polymorphisms (A118G in exon 1 and IVS2+31 in intron 2) of the human -opioid receptor gene (OPRM1) confer susceptibility to opioid dependence.
Methods:
In contrast to classical case–control studies both groups, opioid dependent cases and non-opioid dependent controls were recruited from individuals who have had access to drugs including opioids and who had been sentenced for violation of the "Dangerous Drugs Act" in Germany.
Results:
For the two allelic variants of OPRM1 under study we did not find evidence for association with opioid dependence.
Conclusions. – Despite absence of association we think that this recruitment approach introduced here, is useful since it putatively offers a more adequate matching for case–control association studies of opioid dependent individuals.
