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  Interactions between synaptic homeostatic mechanisms: an attempt to reconcile BCM theory, synaptic scaling, and changing excitation/inhibition balance

Keck, T., Hübener, M., & Bonhoeffer, T. (2017). Interactions between synaptic homeostatic mechanisms: an attempt to reconcile BCM theory, synaptic scaling, and changing excitation/inhibition balance. Current Opinion in Neurobiology, 43, 87-93. doi:10.1016/j.conb.2017.02.003.

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 Urheber:
Keck, Tara1, Autor
Hübener, Mark2, Autor           
Bonhoeffer, Tobias2, Autor           
Affiliations:
1external, ou_persistent22              
2Department: Synapses-Circuits-Plasticity / Bonhoeffer, MPI of Neurobiology, Max Planck Society, ou_1113545              

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Schlagwörter: MOUSE VISUAL-CORTEX; OCULAR DOMINANCE PLASTICITY; FIRING RATE HOMEOSTASIS; LONG-TERM POTENTIATION; AXON INITIAL SEGMENT; IN-VIVO; MONOCULAR DEPRIVATION; DENDRITIC SPINES; AMPA RECEPTOR; DEPENDENT PLASTICITYNeurosciences & Neurology;
 Zusammenfassung: Homeostatic plasticity is proposed to be mediated by synaptic changes, such as synaptic scaling and shifts in the excitation/inhibition balance. These mechanisms are thought to be separate from the Bienenstock, Cooper, Munro (BCM) learning rule, where the threshold for the induction of long-term potentiation and long-term depression slides in response to changes in activity levels. Yet, both sets of mechanisms produce a homeostatic response of a relative increase (or decrease) in strength of excitatory synapses in response to overall activity-level changes. Here we review recent studies, with a focus on in vivo experiments, to re-examine the overlap and differences between these two mechanisms and we suggest how they may interact to facilitate firing-rate homeostasis, while maintaining functional properties of neurons.

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Sprache(n): eng - English
 Datum: 2017
 Publikationsstatus: Erschienen
 Seiten: 7
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: ISI: 000403424400013
DOI: 10.1016/j.conb.2017.02.003
 Art des Abschluß: -

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Titel: Current Opinion in Neurobiology
  Andere : Curr. Opin.Neurobiol.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: New York, NY : Elsevier Current Trends
Seiten: - Band / Heft: 43 Artikelnummer: - Start- / Endseite: 87 - 93 Identifikator: ISSN: 0959-4388
CoNE: https://pure.mpg.de/cone/journals/resource/954925578066