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  MRI sensing of neurotransmitters with a crown-ether appended Gd3+ complex

Oukhatar, F., Même, S., Même, W., Szeremeta, F., Logothetis, N., Angelovski, G., et al. (2015). MRI sensing of neurotransmitters with a crown-ether appended Gd3+ complex. ACS Chemical Neuroscience, 6(2), 219-225. doi:10.1021/cn500289y.

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http://pubs.acs.org/doi/pdf/10.1021/cn500289y (Verlagsversion)
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Oukhatar, F1, 2, Autor           
Même, S, Autor
Même, W, Autor
Szeremeta, F, Autor
Logothetis, NK1, 2, Autor           
Angelovski, G2, 3, Autor           
Toth, E, Autor
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              
3Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528691              

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 Zusammenfassung: Molecular MRI approaches that detect biomarkers associated to neural activity would allow more direct observation of brain function than current functional MRI based on blood-oxygen-level-dependent contrast. Our objective was to create a synthetic molecular platform with appropriate recognition moieties for zwitterionic neurotransmitters that generate an MR signal change upon neurotransmitter binding. The gadolinium complex (GdL) we report offers ditopic binding for zwitterionic amino acid neurotransmitters, via: i) interactions between the positively charged and coordinatively unsaturated metal centre and the carboxylate function and ii) between a triazacrown ether and the amine group of the neurotransmitters. GdL discriminates zwitterionic neurotransmitters from monoamines. Neurotransmitter binding leads to a remarkable relaxivity change, related to a decrease in hydration number. GdL was successfully used to monitor neural activity in ex vivo mouse brain slices by MRI.

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 Datum: 2015-02
 Publikationsstatus: Erschienen
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 Identifikatoren: DOI: 10.1021/cn500289y
BibTex Citekey: OukhatarMMSLAT2014
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Titel: ACS Chemical Neuroscience
Genre der Quelle: Zeitschrift
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Seiten: - Band / Heft: 6 (2) Artikelnummer: - Start- / Endseite: 219 - 225 Identifikator: -