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Schlagwörter:
Angiotensin II; AT(1) receptors; Imnumohistochernistry; Losartan; Rat carotid body; Superior cervical ganglion
Zusammenfassung:
The carotid body (CB) is a major peripheral arterial chemoreceptor that initiates respiratory and cardiovascular adjustments to maintain homeostasis. Recent evidence suggests that circulating or locally produced hormones like angiotensin II acting via AT(1). receptors modulate its activity in a paracrine-autocrine manner. The aim of this study was to examine the immunohistochemical localization of AT(1) receptor in the CB of adult rats and to compare its expression in vehicle-treated animals, and after the long-term application of its selective blocker losartan. Immunohistochemistry revealed that a subset of CB glomenruli and the vast majority of neurons in the adjacent superior cervical ganglion (SCG) were strongly AT(1) receptor-immunoreactive. In the CB immunostaining was observed in the chemosensory glomus cells typically aggregated in cell clusters while the nerve fibers in-between and large capillaries around them were immunonegative. Exogenous administration of losartan for a prolonged time significantly reduces the intensity of AT(1) receptor immunostaining in the CB glomus cells and SCG neurons. Our results show that AT(1) receptors are largely expressed in the rat CB under physiological conditions, and their expression is down-regulated by losartan treatment.
