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  Dendrimeric Calcium-responsive MRI Contrast Agents with Slow in vivo Diffusion

Gündüz, S., Nitta, N., Vibhute, S., Shibata, S., Maier, M., Logothetis, N., et al. (2015). Dendrimeric Calcium-responsive MRI Contrast Agents with Slow in vivo Diffusion. Chemical Communications, 51(14), 2782-2785. doi:10.1039/C4CC07540D.

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Gündüz, S1, 2, Author           
Nitta, N, Author
Vibhute, SM2, 3, Author           
Shibata, S, Author
Maier, ME, Author
Logothetis, NK2, 3, Author           
Aoki, I, Author
Angelovski, G1, 2, Author           
Affiliations:
1Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528691              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              
3Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Abstract: We report a methodology which enables preparation of dendrimeric contrast agents sensitive to Ca2+ when starting from the monomeric analogue. The Ca-triggered longitudinal relaxivity response of these agents is not compromised by undertaken synthetic transformations, despite structural changes. The in vivo MRI studies in rat cerebral cortex indicate that diffusion property of dendrimeric contrast agent has great advantages as compared to its monomeric equivalent.

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 Dates: 2015-01
 Publication Status: Issued
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 Identifiers: DOI: 10.1039/C4CC07540D
BibTex Citekey: GunduzNVSMLAA2014
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Title: Chemical Communications
Source Genre: Journal
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Pages: - Volume / Issue: 51 (14) Sequence Number: - Start / End Page: 2782 - 2785 Identifier: -