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  Accuracy and Precision Analysis in Spectral Fitting: A Lesson Learned from ProFit

Scheidegger, M., Fuchs, A., & Henning, A. (2014). Accuracy and Precision Analysis in Spectral Fitting: A Lesson Learned from ProFit. In Joint Annual Meeting ISMRM-ESMRMB 2014.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0001-33E4-4 Version Permalink: https://hdl.handle.net/21.11116/0000-0001-3726-7
Genre: Meeting Abstract

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http://www.ismrm.org/14/program_files/Session63.htm (Abstract)
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 Creators:
Scheidegger, M, Author
Fuchs, A, Author
Henning, Anke1, 2, Author           
Affiliations:
1Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528692              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: This work demonstrates that both accuracy and precision are important to evaluate for performance validation of spectral fitting packages as demonstrated on the example of ProFit – a spectral fitting package for 2D JPRESS. Strong regularization or tight constraints as implemented in different commercial or freely available spectral fitting routines can lead to small coefficients of variance but strong bias of the quantification results which hinder the detection of naturally occurring variance of metabolite concentrations.

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 Dates: 2014-05
 Publication Status: Issued
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 Identifiers: BibTex Citekey: ScheideggerFH2014
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Title: Joint Annual Meeting ISMRM-ESMRMB 2014
Place of Event: Milano, Italy
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Title: Joint Annual Meeting ISMRM-ESMRMB 2014
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 0813 Start / End Page: - Identifier: -