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  Mapping sequence structure in the human lateral entorhinal cortex

Bellmund, J. L. S., Deuker, L., & Doeller, C. F. (2019). Mapping sequence structure in the human lateral entorhinal cortex. eLife, e45333. doi:10.7554/eLife.45333.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0004-88F4-F Version Permalink: https://hdl.handle.net/21.11116/0000-0004-F088-3
Genre: Journal Article

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 Creators:
Bellmund, Jacob L. S.1, 2, 3, Author           
Deuker, Lorena4, Author
Doeller, Christian F.1, 2, Author           
Affiliations:
1Department Psychology (Doeller), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2591710              
2Kavli Institute for Systems Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway, ou_persistent22              
3Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
4Department of Neuropsychology, Institute for Cognitive Neuroscience, Ruhr University, Bochum, Germany, ou_persistent22              

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Free keywords: Grid cells; Temporal context; Object representation; Time cells; Memory; Hippocampus; Retrieval; Information; Population; Systems
 Abstract: Remembering event sequences is central to episodic memory and presumablysupported by the hippocampal-entorhinal region. We previously demonstrated that thehippocampus maps spatial and temporal distances between events encountered along a routethrough a virtual city (Deuker et al., 2016), but the content of entorhinal mnemonic representationsremains unclear. Here, we demonstrate that multi-voxel representations in the anterior-lateralentorhinal cortex (alEC) — the human homologue of the rodent lateral entorhinal cortex —specifically reflect the temporal event structure after learning. Holistic representations of thesequence structure related to memory recall and the timeline of events could be reconstructedfrom entorhinal multi-voxel patterns. Our findings demonstrate representations of temporalstructure in the alEC; dovetailing with temporal information carried by population signals in thelateral entorhinal cortex of navigating rodents and alEC activations during temporal memoryretrieval. Our results provide novel evidence for the role of the alEC in representing time forepisodic memory.

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Language(s): eng - English
 Dates: 2019-01-252019-07-162019-08-06
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.7554/eLife.45333
PMID: 31383256
PMC: PMC6684227
 Degree: -

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Project name : -
Grant ID : -
Funding program : -
Funding organization : Max Planck Society
Project name : Cognitive Geometry: Deciphering neural concept spaces and engineering knowledge to empower smart brains in a smart society / GEOCOG
Grant ID : 724836
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : -
Grant ID : 452‐12‐ 009
Funding program : Vidi-Grant
Funding organization : Netherlands Organisation for Scientific Research (NWO)
Project name : -
Grant ID : 024‐001‐006
Funding program : NWO-Gravitation
Funding organization : Netherlands Organisation for Scientific Research (NWO)
Project name : -
Grant ID : 406‐14‐114 ; 406‐15‐291
Funding program : NWO-MaGW
Funding organization : Netherlands Organisation for Scientific Research (NWO)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Kavli Foundation
Project name : -
Grant ID : 223262
Funding program : -
Funding organization : Research Council of Norway
Project name : -
Grant ID : -
Funding program : -
Funding organization : The Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits
Project name : NORBRAIN
Grant ID : -
Funding program : National Infrastructure scheme of the Research Council of Norway
Funding organization : Research Council of Norway

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Title: eLife
Source Genre: Journal
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: - Volume / Issue: - Sequence Number: e45333 Start / End Page: - Identifier: ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X