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  Identification of Synaptophysin as a Hexameric Channel Protein of the Synaptic Vesicle Membrane

Thomas, L., Hartung, K., Langosch, D., Rehm, H., Bamberg, E., Franke, W. W., et al. (1988). Identification of Synaptophysin as a Hexameric Channel Protein of the Synaptic Vesicle Membrane. Science, 242(4881), 1050-1053. doi:10.1126/science.2461586.

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 Creators:
Thomas, Leo1, Author
Hartung, Klaus2, Author              
Langosch, Dieter1, Author
Rehm, Hubert1, Author
Bamberg, Ernst2, Author              
Franke, Werner W.3, Author
Betz, Heinrich1, Author
Affiliations:
1Zentrum für Molekulare Biologie, Universität Heidelberg, Germany., ou_persistent22              
2Transport Proteins Group, Max Planck Institute of Biophysics, Max Planck Society, ou_3273415              
3Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 28, 6900 Heidelberg, Germany, ou_persistent22              

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 Abstract: The quaternary structure and functional properties of synaptophysin, a major integral membrane protein of small presynaptic vesicles, were investigated. Cross-linking and sedimentation studies indicate that synaptophysin is a hexameric homo-oligomer, which in electron micrographs exhibits structural features common to channel-forming proteins. On reconstitution into planar lipid bilayers, purified synaptophysin displays voltage-sensitive channel activity with an average conductance of about 150 picosiemens. Because specific channels and fusion pores have been implicated in vesicular uptake and release of secretory compounds, synaptophysin may have a role in these processes.

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Language(s): eng - English
 Dates: 1988-06-171988-09-091988-11-18
 Publication Status: Published in print
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1126/science.2461586
PMID: 246158
 Degree: -

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Title: Science
  Abbreviation : Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 242 (4881) Sequence Number: - Start / End Page: 1050 - 1053 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1