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  Cell Division: Flipping the Mitotic Switches

Zachariae, W., & Tyson, J. J. (2016). Cell Division: Flipping the Mitotic Switches. Current Biology, 26(24), R1272-R1274. doi:10.1016/j.cub.2016.11.007.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-57A0-3 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-57A1-1
Genre: Journal Article

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http://www.sciencedirect.com/science/article/pii/S096098221631332X (Publisher version)
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 Creators:
Zachariae, Wolfgang1, Author           
Tyson, John J.2, Author
Affiliations:
1Zachariae, Wolfgang / Chromosome Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565176              
2external, ou_persistent22              

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Free keywords: CYCLE TRANSITIONS; M-PHASE; HYSTERESIS; EXTRACTS; MITOSIS; EXITBiochemistry & Molecular Biology; Cell Biology;
 Abstract: Alternation between DNA replication in the mother cell (S phase) and equal partitioning of the replicated chromosomes to the daughter cells (M phase) during eukaryotic cell division is governed by switches that flip protein kinases on and off. New work reveals that the M-phase promoting kinase is opposed by a phosphatase that also participates in a bistable switching mechanism.

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Language(s): eng - English
 Dates: 2016-12-192016
 Publication Status: Issued
 Pages: 3
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000390666200009
DOI: 10.1016/j.cub.2016.11.007
 Degree: -

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Title: Current Biology
  Other : Curr. Biol.
Source Genre: Journal
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Publ. Info: London, UK : Cell Press
Pages: - Volume / Issue: 26 (24) Sequence Number: - Start / End Page: R1272 - R1274 Identifier: ISSN: 0960-9822
CoNE: https://pure.mpg.de/cone/journals/resource/954925579107