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  CRISPR}-{Cas} in {Streptococcus pyogenes

Le Rhun, A., Escalera-Maurer, A., Bratovič, M., & Charpentier, E. (2019). CRISPR}-{Cas} in {Streptococcus pyogenes. RNA biology, 16(4), 380-389. doi:10.1080/15476286.2019.1582974.

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Genre: Journal Article

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Le Rhun, Anaïs1, Author
Escalera-Maurer, Andrés, Author
Bratovič, Majda, Author
Charpentier, Emmanuelle, Author
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1External Organizations, ou_persistent22              

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Free keywords: Adaptation, Physiological, adaptive immune system, Cas9, CRISPR, CRISPR-Cas Systems, Genetic Loci, genome editing, mobile genetic elements, phages, RNA, RNA Interference, Streptococcus pyogenes
 Abstract: The discovery and characterization of the prokaryotic CRISPR-Cas immune system has led to a revolution in genome editing and engineering technologies. Despite the fact that most applications emerged after the discovery of the type II-A CRISPR-Cas9 system of Streptococcus pyogenes, its biological importance in this organism has received little attention. Here, we provide a comprehensive overview of the current knowledge about CRISPR-Cas systems from S. pyogenes. We discuss how the interplay between CRISPR-mediated immunity and horizontal gene transfer might have modeled the evolution of this pathogen. We review the current literature about the CRISPR-Cas systems present in S. pyogenes (types I-C and II-A), and describe their distinctive biochemical and functional features. Finally, we summarize the main biotechnological applications that have arisen from the discovery of the CRISPR-Cas9 system in S. pyogenes.

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 Dates: 2019-04
 Publication Status: Published in print
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 Identifiers: DOI: 10.1080/15476286.2019.1582974
BibTex Citekey: le_rhun_crispr-cas_2019
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Title: RNA biology
Source Genre: Journal
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Pages: - Volume / Issue: 16 (4) Sequence Number: - Start / End Page: 380 - 389 Identifier: ISSN: 1555-8584