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  Comparative study on the conformation of phalloidin, viroisin, and related derivatives in aqueous solution

Kobayashi, N., Endo, S., Kobayashi, H., Faulstich, H., Wieland, T., & Munekata, E. (1995). Comparative study on the conformation of phalloidin, viroisin, and related derivatives in aqueous solution. European Journal of Biochemistry, 232(3), 726-736. doi:10.1111/j.1432-1033.1995.726zz.x.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-7480-5 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-7481-3
Genre: Journal Article
Alternative Title : Comparative study on the conformation of phalloidin, viroisin, and related derivatives in aqueous solution

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 Creators:
Kobayashi, Naohiro, Author
Endo, Satoshi, Author
Kobayashi, Hideyuki, Author
Faulstich, Heinz1, Author           
Wieland, Theodor2, Author           
Munekata, Eisuke, Author
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1Department of Molecular Cell Research, Max Planck Institute for Medical Research, Max Planck Society, ou_1497703              
2Max Planck Institute for Medical Research, Max Planck Society, ou_1125545              

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Free keywords: phalloidin ; viroisin ; NMR ; conformation
 Abstract: We investigated the conformations of toxic phalloidin and viroisin in aqueous solution using 500-MHz 1H-NMR spectroscopy in conjunction with molecular modeling. The conformations of two non-toxic phalloidin derivatives, secophalloidin and dethiophalloidin, were also correspondingly studied for comparison purposes. Results indicate that the non-toxic peptides have a multiple conformation, whereas the toxic peptides are comprised of a rigid molecule. It was found that the conformation of phalloidin partially resembles that of viroisin in the region of Cys3-Pro4-Ala5-Trp6, being different from that of the non-toxic peptides; thereby suggesting this region plays an important role leading to their toxicity.

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Language(s): eng - English
 Dates: 1995-04-121995-09-15
 Publication Status: Issued
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 665231
DOI: 10.1111/j.1432-1033.1995.726zz.x
URI: http://www.ncbi.nlm.nih.gov/pubmed/7588710
Other: 6876
 Degree: -

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Title: European Journal of Biochemistry
Source Genre: Journal
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Publ. Info: Berlin : Published by Springer-Verlag on behalf of the Federation of European Biochemical Societies
Pages: - Volume / Issue: 232 (3) Sequence Number: - Start / End Page: 726 - 736 Identifier: ISSN: 0014-2956
CoNE: https://pure.mpg.de/cone/journals/resource/111097776606040