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  GluR-A-Deficient mice display normal acquisition of a hippocampus-dependent spatial reference memory task but are impaired during spatial reversal

Bannerman, D. M., Deacon, R. M. J., Seeburg, P. H., & Rawlins, J. N. P. (2003). GluR-A-Deficient mice display normal acquisition of a hippocampus-dependent spatial reference memory task but are impaired during spatial reversal. Behavioral Neuroscience, 117(4), 866-870. doi:10.1037/0735-7044.117.4.866.

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Genre: Journal Article
Alternative Title : GluR-A-Deficient mice display normal acquisition of a hippocampus-dependent spatial reference memory task but are impaired during spatial reversal

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BehavNeurosci_117_2003_866.pdf (Any fulltext), 98KB
 
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Bannerman, David M., Author
Deacon, Robert M. J., Author
Seeburg, Peter H.1, Author              
Rawlins, John Nicholas P., Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: Acquisition and reversal of a spatial discrimination were assessed in an appetitive, elevated plus-maze task in 4 groups of mice: knockout mice lacking the AMPA receptor subunit GluR-A (GluR1), wild-type controls, mice with cytotoxic hippocampal lesions, and controls that had undergone sham surgery. In agreement with previous studies using tasks such as the water maze, GluR-A(-/-) mice were unimpaired during acquisition of the spatial discrimination task, whereas performance in the hippocampalgroup remained at chance levels. In contrast to their performance during acquisition, the GluR-A(-/-) mice displayed a mild deficit during reversal of the spatial discrimination and were profoundly impaired during discrete trial, rewarded-alternation testing on the elevated T maze. The latter result suggests a short-term, flexible spatial working memory impairment in GluR-A(-/-) mice, which might also underlie their mild deficit during spatial reversal.

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Language(s): eng - English
 Dates: 2002-11-122003-02-172003-08-01
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
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Title: Behavioral Neuroscience
Source Genre: Journal
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Publ. Info: Baltimore, Md. : American Psychological Association (PsycARTICLES)
Pages: - Volume / Issue: 117 (4) Sequence Number: - Start / End Page: 866 - 870 Identifier: ISSN: 0735-7044
CoNE: https://pure.mpg.de/cone/journals/resource/954927546238