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  Synthesis and Characterization of a Smart Contrast Agent Sensitive to Calcium

Dhingra, K., Maier, M., Beyerlein, M., Angelovski, G., & Logothetis, N. (2008). Synthesis and Characterization of a Smart Contrast Agent Sensitive to Calcium. Chemical Communications, 29, 3444-3446. doi:10.1039/b801975d.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0013-C8DF-F Version Permalink: https://hdl.handle.net/21.11116/0000-0003-305E-E
Genre: Journal Article

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https://pubs.rsc.org/en/content/articlepdf/2008/cc/b801975d (Publisher version)
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 Creators:
Dhingra, K1, 2, Author           
Maier, ME, Author
Beyerlein, M1, 2, Author           
Angelovski, G1, 2, Author           
Logothetis, NK1, 2, Author           
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: A novel first-generation Ca2+ sensitive contrast agent, Gd-DOPTRA has been synthesized and characterized. The agent shows 100 relaxivity enhancement upon addition of Ca2+. The agent is selective and sensitive to Ca2+ also in the presence of Mg2+ and Zn2+. The relaxivity studies carried out in physiological fluids prove the prospects of the agent for in vivo measurements.

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 Dates: 2008-06
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1039/b801975d
BibTex Citekey: 5128
 Degree: -

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Title: Chemical Communications
  Other : Chem. Commun.
Source Genre: Journal
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Publ. Info: Cambridge, UK : Royal Society of Chemistry
Pages: - Volume / Issue: 29 Sequence Number: - Start / End Page: 3444 - 3446 Identifier: ISSN: 1359-7345
CoNE: https://pure.mpg.de/cone/journals/resource/954928495413