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  Calcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple Sclerosis

Witte, M. E., Schumacher, A.-M., Mahler, C. F., Bewersdorf, J. P., Lehmitz, J., Scheiter, A., et al. (2019). Calcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple Sclerosis. Neuron, 101(4), 615-624.e5. doi:10.1016/j.neuron.2018.12.023.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0003-68A5-E Version Permalink: https://hdl.handle.net/21.11116/0000-0003-68AA-9
Genre: Journal Article

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 Creators:
Witte, Maarten E.1, Author
Schumacher, Adrian-Minh1, Author
Mahler, Christoph F.1, Author
Bewersdorf, Jan P.1, Author
Lehmitz, Jonas1, Author
Scheiter, Alexander1, Author
Sanchez, Paula1, Author
Williams, Philip R.1, Author
Griesbeck, Oliver2, Author           
Naumann, Ronald1, Author
Misgeld, Thomas1, Author
Kerschensteiner, Martin1, Author
Affiliations:
1external, ou_persistent22              
2Research Group: Tools for Bio-Imaging / Griesbeck, MPI of Neurobiology, Max Planck Society, ou_1113560              

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Free keywords: SECONDARY DEGENERATION; CA2+ RELEASE; MECHANISMS; INJURY; DYSFUNCTION; NEURONS; STRESS; DAMAGE; CNSNeurosciences & Neurology;
 Abstract: Axon loss determines persistent disability in multiple sclerosis patients. Here, we use in vivo calcium imaging in a multiple sclerosis model to show that cytoplasmic calcium levels determine the choice between axon loss and survival. We rule out the endoplasmic reticulum, glutamate excitotoxicity, and the reversal of the sodium-calcium exchanger as sources of intra-axonal calcium accumulation and instead identify nanoscale ruptures of the axonal plasma membrane as the critical path of calcium entry.

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Language(s): eng - English
 Dates: 2019-01-242019-02
 Publication Status: Issued
 Pages: 15
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000459127000011
DOI: 10.1016/j.neuron.2018.12.023
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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 101 (4) Sequence Number: - Start / End Page: 615 - 624.e5 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565