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  Higher body mass index in older adults is associated with lower gray matter volume: Implications for memory performance

Kharabian, S., Arélin, K., Horstmann, A., Lampe, L., Kipping, J., Luck, T., Riedel-Heller, S., Schroeter, M. L., Stumvoll, M., Villringer, A., & Witte, V. (2016). Higher body mass index in older adults is associated with lower gray matter volume: Implications for memory performance. Neurobiology of Aging, 40, 1-10. doi:10.1016/j.neurobiolaging.2015.12.020.

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アイテムのパーマリンク: https://hdl.handle.net/11858/00-001M-0000-0029-4DA4-3 版のパーマリンク: https://hdl.handle.net/21.11116/0000-0003-1A5C-A
資料種別: 学術論文

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URL:
http://www.sciencedirect.com/science/article/pii/S0197458015006363 (全文テキスト（全般）)
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 作成者:
Kharabian, Shahrzad1, 著者           
Arélin, Katrin1, 2, 3, 著者           
Horstmann, Annette1, 4, 著者           
Lampe, Leonie1, 2, 著者           
Kipping, Judy1, 著者           
Luck, Tobias2, 5, 著者
Riedel-Heller, Steffi5, 著者
Schroeter, Matthias L.1, 3, 4, 著者           
Stumvoll, Michael4, 6, 著者
Villringer, Arno1, 3, 6, 著者           
Witte, Veronica1, 6, 著者           
所属:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
4Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
5Institute of Social Medicine, Occupational Health and Public Health (ISAP), University Hospital Leipzig, Germany, ou_persistent22              
6Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              

内容説明

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キーワード: Cognitive ageing; VBM; Cognitive performance; Healthy aging; Lifestyle factors; Overweight; Adiposity; Cohort studies
 要旨: Midlife obesity has been associated with increased dementia risk, yet reports on brain structure and function are mixed. We therefore assessed the effects of body mass index (BMI) on gray matter volume (GMV) and cognition in a well-characterized sample of community-dwelled older adults. GMV was measured using 3T-neuroimaging in 617 participants (258 women, 60-80 years, BMI 17-41 kg/m2). Also, cognitive performance and various confounders including hypertension, diabetes and APOE-genotype were assessed. A higher BMI correlated significantly with lower GMV in multiple brain regions, including (pre)frontal, temporal, insular and occipital cortex, thalamus, putamen, amygdala and cerebellum, even after adjusting for confounders. Also, lower GMV in prefrontal and thalamic areas partially mediated negative effects of (1) higher BMI and (2) higher age on memory performance. We here showed that a higher BMI in older adults is associated with widespread gray matter alterations, irrespective of obesity-related co-morbidities and other confounders. Our results further indicate that a higher BMI induces structural alterations that translate into subtle impairments in memory performance in aging.

資料詳細

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言語: eng - English
 日付: 2015-12-282015-06-242015-12-282016-01-042016-04
 出版の状態: 出版
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子（DOI, ISBNなど）: DOI: 10.1016/j.neurobiolaging.2015.12.020
PMID: 26973099
その他: Epub 2016
 学位: -

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出版物 1

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出版物名: Neurobiology of Aging
  その他 : Neurobiol. Aging
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: -
ページ: - 巻号: 40 通巻号: - 開始・終了ページ: 1 - 10 識別子（ISBN, ISSN, DOIなど）: ISSN: 0197-4580
CoNE: https://pure.mpg.de/cone/journals/resource/954925491902