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  Interferon-beta-1b increases serum interleukin-12 p40 levels in primary progressive multiple sclerosis patients

Bahner, D., Klucke, C., Kitze, B., Elitok, E., Bogumil, T., Dressel, A., et al. (2002). Interferon-beta-1b increases serum interleukin-12 p40 levels in primary progressive multiple sclerosis patients. Neuroscience Letters, 326(2), 125-128.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A1C1-C Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-A1C2-A
Genre: Zeitschriftenartikel
Alternativer Titel : Neurosci. Lett.

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 Urheber:
Bahner, D1, Autor
Klucke, C1, Autor
Kitze, B1, Autor
Elitok, E1, Autor
Bogumil, T1, Autor
Dressel, A1, Autor
Tumani, H1, Autor
Weber, F1, Autor
Poser, S1, Autor
Bitsch, A-1, Autor
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

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Schlagwörter: primary progressive multiple sclerosis; interferon-beta-1b; interleukin-12; cytokines
 Zusammenfassung: Serum levels of interleukin-12 heterodimer (IL-12p70) and its homodimeric subunit (IL-12p40) were analyzed by enzyme-linked immunosorbent assay in 18 patients with primary progressive multiple sclerosis (MS) during 3 months before and 3 months under treatment with interferon-beta-1b (IFNbeta-1b, Betaferon(TM), eight million units (MIU) every other day subcutaneously). Median IL-12p40 levels in MS patients before treatment (66.5 and 63.9 pg/ml) were not elevated compared to 18 healthy controls. IL-12p40 significantly increased during treatment (P < 0.0001, median 105.3 pg/ml after 1 month and 95.3 pg/ml after 3 months). Detectable serum levels of IL-12p70 before therapy were only found in one patient. IL-12p70 did not increase during treatment. These data show that immunological processes may also play a role in primary progressive MS and that IFNbeta-1b has an immunomodulating effect in this particular MS subtype. (C) 2002 Published by Elsevier Science Ireland Ltd

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Sprache(n): eng - English
 Datum: 2002-06-28
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 4126
ISI: 000176623000014
 Art des Abschluß: -

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Titel: Neuroscience Letters
  Alternativer Titel : Neurosci. Lett.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 326 (2) Artikelnummer: - Start- / Endseite: 125 - 128 Identifikator: ISSN: 0304-3940