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  Transport Proteins on Solid-Supported Membranes: From Basic Research to Drug Discovery

Fendler, K., Klingenberg, M., Leblanc, G., DePont, J. J. H., Kelety, B., Dörner, W., et al. (2004). Transport Proteins on Solid-Supported Membranes: From Basic Research to Drug Discovery. In V. M. Vladimir M. (Ed.), Springer Series on Chemical Sensors and Biosensors (Methods and Applications) (pp. 331-349). Berlin, Heidelberg: Springer-Verlag.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0009-29A3-1 Versions-Permalink: https://hdl.handle.net/21.11116/0000-0009-29A4-0
Genre: Buchkapitel

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 Urheber:
Fendler, Klaus1, Autor           
Klingenberg, Martin2, Autor
Leblanc, Gerard2, Autor
DePont, Jan Joep H.H.M.2, Autor
Kelety, Béla1, Autor           
Dörner, Wolfgang2, Autor
Bamberg, Ernst1, Autor           
Affiliations:
1Department of Biophysical Chemistry, Max Planck Institute of Biophysics, Max Planck Society, ou_2068289              
2External Organizations, ou_persistent22              

Inhalt

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Schlagwörter: Solid-supported membrane; Electrogenic; Membrane protein; Drug discovery; Drug screening
 Zusammenfassung: Solid-supported membranes (SSM) can be used as capacitive electrodes for the investigation of electrogenic transport proteins (ion pumps). Membrane fragments or liposomes that contain the transport protein are adsorbed on the SSM. The proteins are activated by supplying a substrate via a rapid solution exchange at the SSM. The charge translocations during the reaction cycle of the transport protein can be measured via the capacitance of the SSM. The SSM and the adsorbed membrane fragments or proteoliposomes represent a rugged structure that can be used in basic research and drug discovery. On the basis of a few examples we demonstrate how this technique can be applied to the investigation of the transport mechanism of membrane proteins. In addition, we present the application of the system in drug discovery. A sensor based on the SSM technology represents a promising system for the rapid screening of pharmaceutically relevant compounds for transport proteins.

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Sprache(n): eng - English
 Datum: 2004
 Publikationsstatus: Erschienen
 Seiten: 18
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1007/978-3-662-05204-4_13
 Art des Abschluß: -

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Titel: Springer Series on Chemical Sensors and Biosensors (Methods and Applications)
  Untertitel : Ultrathin Electrochemical Chemo- and Biosensors
  Untertitel : Technology and Performance
Genre der Quelle: Reihe
 Urheber:
Vladimir M., Vladimir M.1, Herausgeber
Affiliations:
1 Institute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg, Regensburg, Germany, ou_persistent22            
Ort, Verlag, Ausgabe: Berlin, Heidelberg : Springer-Verlag
Seiten: 358 Band / Heft: 2 Artikelnummer: - Start- / Endseite: 331 - 349 Identifikator: DOI: 10.1007/978-3-662-05204-4
ISBN: 978-3-540-21285-0
ISBN: 978-3-662-05204-4
ISSN: 1612-7617