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  Epigenetic modification of the oxytocin receptor gene is associated with emotion processing in the infant brain

Krol, K. M., Puglia, M. H., Morris, J. P., Connelly, J. J., & Grossmann, T. (2019). Epigenetic modification of the oxytocin receptor gene is associated with emotion processing in the infant brain. Developmental Cognitive Neuroscience, 37: 100648. doi:10.1016/j.dcn.2019.100648.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0004-91A5-D Version Permalink: https://hdl.handle.net/21.11116/0000-0004-E483-6
Genre: Journal Article

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 Creators:
Krol, K. M.1, 2, Author           
Puglia, Meghan H.1, Author
Morris, James P.1, Author
Connelly, Jessica J.1, Author
Grossmann, Tobias1, 2, Author           
Affiliations:
1Department of Psychology, University of Virginia, Charlottesville, VA, USA, ou_persistent22              
2Max Planck Research Group Early Social Development, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1356545              

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Free keywords: DNA methylation; Emotion; Epigenetics; Infancy; Inferior frontal cortex; Oxytocin; fNIRS
 Abstract: The neural capacity to discriminate between emotions emerges early in development, though little is known about specific factors that contribute to variability in this vital skill during infancy. In adults, DNA methylation of the oxytocin receptor gene (OXTRm) is an epigenetic modification that is variable, predictive of gene expression, and has been linked to autism spectrum disorder and the neural response to social cues. It is unknown whether OXTRm is variable in infants, and whether it is predictive of early social function. Implementing a developmental neuroimaging epigenetics approach in a large sample of infants (N = 98), we examined whether OXTRm is associated with neural responses to emotional expressions. OXTRm was assessed at 5 months of age. At 7 months of age, infants viewed happy, angry, and fearful faces while functional near-infrared spectroscopy was recorded. We observed that OXTRm shows considerable variability among infants. Critically, infants with higher OXTRm show enhanced responses to anger and fear and attenuated responses to happiness in right inferior frontal cortex, a region implicated in emotion processing through action-perception coupling. Findings support models emphasizing oxytocin's role in modulating neural response to emotion and identify OXTRm as an epigenetic mark contributing to early brain function.

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Language(s): eng - English
 Dates: 2019-04-182018-08-242019-04-182019-04-26
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.dcn.2019.100648
PMID: 31125951
Other: Epub 2019
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Funding organization : Max Planck Society
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Funding organization : University of Virginia
Project name : -
Grant ID : -
Funding program : International Max Planck Research School Scholarship
Funding organization : International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity (IMPRS NeuroCom)
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Grant ID : -
Funding program : Research Training in Neuroendocrinology Fellowship (NIH NRSA T32)
Funding organization : National Institutes of Health (NIH)
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Funding program : Hartwell Biomedical Research Fellowship
Funding organization : The Hartwell Foundation
Project name : Examining an Epigenetic Biomarker of Social Perception
Grant ID : 1228522
Funding program : -
Funding organization : National Science Foundation (NSF)
Project name : Epigenetic influences on the early development of social brain functions
Grant ID : 1729289
Funding program : -
Funding organization : National Science Foundation (NSF)

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Title: Developmental Cognitive Neuroscience
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 37 Sequence Number: 100648 Start / End Page: - Identifier: ISSN: 1878-9293
CoNE: https://pure.mpg.de/cone/journals/resource/1878-9293