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  A chemogenetic approach for the optical monitoring of voltage in neurons

Sundukova, M., Prifti, E., Bucci, A., Kirillova, K., Serrao, J., Reymond, L., et al. (2019). A chemogenetic approach for the optical monitoring of voltage in neurons. Angewandte Chemie International Edition, 58(8), 2341-2344. doi:10.1002/anie.201812967.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0002-E506-5 Version Permalink: https://hdl.handle.net/21.11116/0000-0007-B632-3
Genre: Journal Article

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 Creators:
Sundukova, Mayya, Author
Prifti, Efthymia, Author
Bucci, Annalisa, Author
Kirillova, Kseniia, Author
Serrao, Joana, Author
Reymond, Luc, Author
Umebayashi, Miwa, Author
Hovius, Ruud, Author
Riezman, Howard, Author
Johnsson, Kai1, Author           
Heppenstall, Paul A., Author
Affiliations:
1Chemical Biology, Max Planck Institute for Medical Research, Max Planck Society, ou_2364732              

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Free keywords: fluorogenic probes; genetic targeting; membrane potential probes; protein tags; voltage imaging
 Abstract: Optical monitoring of neuronal voltage using fluorescent indicators is a powerful approach for the interrogation of the cellular and molecular logic of the nervous system. Herein, a semisynthetic tethered voltage indicator (STeVI1) based upon nile red is described that displays voltage sensitivity when genetically targeted to neuronal membranes. This environmentally sensitive probe allows for wash-free imaging and faithfully detects supra- and sub-threshold activity in neurons.

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Language(s): eng - English
 Dates: 2018-12-162018-11-122018-12-202018-12-202019-02-18
 Publication Status: Issued
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/anie.201812967
URI: https://pubmed.ncbi.nlm.nih.gov/30569539/
 Degree: -

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Title: Angewandte Chemie International Edition
  Other : Angewandte Chemie, International Edition
  Other : Angew. Chem. Int. Ed.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: 58 (8) Sequence Number: - Start / End Page: 2341 - 2344 Identifier: ISSN: 1433-7851
CoNE: https://pure.mpg.de/cone/journals/resource/1433-7851