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Abstract:
A multi-modal fMRI platform is developed for a better understanding of the neuron-glio-vascular interaction in normal and diseased brain states of animals. Combining the single-vessel fMRI method with optogenetics and genetically encoded calcium indicators enables to identify the specific contributions of distinct vascular and cellular components to the fMRI signal. The translational application of this work is to identify vessel-specific dynamic biomarkers of patients with vascular dementia, ranging from small vessel diseases to degenerative diseases, such as Alzheimer’s.
