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  Identifying the perfusion deficit in acute stroke with resting-state functional magnetic resonance imaging

Lv, Y., Margulies, D. S., Craddock, R. C., Long, X., Winter, B., Gierhake, D., et al. (2013). Identifying the perfusion deficit in acute stroke with resting-state functional magnetic resonance imaging. Annals of Neurology, 73(1), 136-140. doi:10.1002/ana.23763.

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Lv_2013_Identifying.pdf (Verlagsversion), 396KB
 
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Lv, Yating1, 2, Autor           
Margulies, Daniel S.1, 2, Autor           
Craddock, R. Cameron3, Autor
Long, Xiangyu1, Autor           
Winter, Benjamin4, 5, Autor
Gierhake, Daniel4, 5, Autor
Endres, Matthias2, 4, 5, 6, Autor
Villringer, Kersten4, 5, Autor
Fiebach, Jochen4, 5, Autor
Villringer, Arno1, 2, 4, 5, Autor           
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Mind and Brain Institute and Berlin School of Mind and Brain, Charité and Humboldt University, Berlin, Germany, ou_persistent22              
3Virginia Tech Carilion Research Institute, Roanoke, VA, ou_persistent22              
4Center for Stroke Research, Charité–Universitätsmedizin, Berlin, Germany, ou_persistent22              
5Department of Neurology, Charité–Universitätsmedizin, Berlin, Germany, ou_persistent22              
6Neurocure Cluster of Excellence, Charité–Universitätsmedizin, Berlin, Germany, ou_persistent22              

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 Zusammenfassung: Temporal delay in blood oxygenation level–dependent (BOLD) signals may be sensitive to perfusion deficits in acute stroke. Resting-state functional magnetic resonance imaging (rsfMRI) was added to a standard stroke MRI protocol. We calculated the time delay between the BOLD signal at each voxel and the whole-brain signal using time-lagged correlation and compared the results to mean transit time derived using bolus tracking. In all 11 patients, areas exhibiting significant delay in BOLD signal corresponded to areas of hypoperfusion identified by contrast-based perfusion MRI. Time delay analysis of rsfMRI provides information comparable to that of conventional perfusion MRI without the need for contrast agents.

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Sprache(n): eng - English
 Datum: 2012-08-202011-11-102012-08-312013-02-012013-01
 Publikationsstatus: Erschienen
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 Ort, Verlag, Ausgabe: -
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 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1002/ana.23763
PMID: 23378326
 Art des Abschluß: -

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Titel: Annals of Neurology
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Boston : American Neurological Association
Seiten: - Band / Heft: 73 (1) Artikelnummer: - Start- / Endseite: 136 - 140 Identifikator: ISSN: 0364-5134
CoNE: https://pure.mpg.de/cone/journals/resource/954925523748