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Schlagwörter:
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Zusammenfassung:
OBJECTIVE: To assess and visualize gravitational effects on brain
morphology and the position of the brain within the skull by magnetic
resonance (MR) morphometry in order to identify confounding effects and
possible sources of error for accurate planning of neurosurgical
interventions.
METHODS: Three-dimensional MR imaging data sets of 13 healthy adults
were acquired in different positions in the scanner. With a
morphometric approach, data sets were evaluated by deformation field
analysis and the brain boundary shift integral. Distortions of the
brain were assessed comparing right versus left and prone versus supine
positioning, respectively.
RESULTS: Two effects could be differentiated: 1) greatest brain
deformation of up to 1.7 mm predominantly located around central brain
structures in the lateral direction and a less pronounced change after
position changes in posterior-anterior direction, and 2) the brain
boundary shift integral depicted position-dependent brain shift
relative to the inner skull.
CONCLUSION: Position-dependent effects on brain structure may undermine
the accuracy of neuronavigational and other neurosurgical procedures.
Furthermore, in longitudinal MR volumetric studies, gravitational
effects should be kept in mind and the scanning position should be
rigidly controlled for.
