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  Emergence of human-adapted Salmonella enterica is linked to the Neolithization process

Key, F. M., Posth, C., Esquivel Gomez, L. R., Hübler, R., Spyrou, M. A., Neumann, G. U., et al. (2020). Emergence of human-adapted Salmonella enterica is linked to the Neolithization process. Nature Ecology & Evolution, 4(3), 324-333. doi:10.1038/s41559-020-1106-9.

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Key, Felix M.1, Autor           
Posth, Cosimo1, Autor           
Esquivel Gomez, Luis Roger2, Autor           
Hübler, Ron1, Autor           
Spyrou, Maria A.1, Autor           
Neumann, Gunnar U.1, Autor           
Furtwängler, Anja, Autor
Sabin, Susanna1, Autor           
Burri Promerová, Marta1, Autor           
Wissgott, Antje1, Autor           
Lankapalli, Aditya Kumar1, Autor           
Vågene, Åshild J.1, Autor           
Meyer, Matthias, Autor
Nagel, Sarah, Autor
Tukhbatova, Rezeda1, Autor           
Khokhlov, Aleksandr, Autor
Chizhevsky, Andrey, Autor
Hansen, Svend, Autor
Belinsky, Andrey B., Autor
Kalmykov, Alexey, Autor
Kantorovich, Anatoly R., AutorMaslov, Vladimir E., AutorStockhammer, Philipp W.3, Autor           Vai, Stefania, AutorZavattaro, Monica, AutorRiga, Alessandro, AutorCaramelli, David, AutorSkeates, Robin, AutorBeckett, Jessica, AutorGradoli, Maria Giuseppina, AutorSteuri, Noah, AutorHafner, Albert, AutorRamstein, Marianne, AutorSiebke, Inga, AutorLösch, Sandra, AutorErdal, Yilmaz Selim, AutorAlikhan, Nabil-Fareed, AutorZhou, Zhemin, AutorAchtman, Mark, AutorBos, Kirsten4, Autor           Reinhold, Sabine, AutorHaak, Wolfgang1, Autor           Kühnert, Denise2, Autor           Herbig, Alexander1, Autor           Krause, Johannes3, Autor            mehr..
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              
2tide, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2591691              
3MHAAM, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2541699              
4CoDisEASe, Max Planck Institute for the Science of Human History, Max Planck Society, ou_3033585              

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 Zusammenfassung: It has been hypothesized that the Neolithic transition towards an agricultural and pastoralist economy facilitated the emergence of human-adapted pathogens. Here, we recovered eight Salmonella enterica subsp. enterica genomes from human skeletons of transitional foragers, pastoralists and agropastoralists in western Eurasia that were up to 6,500 yr old. Despite the high genetic diversity of S. enterica, all ancient bacterial genomes clustered in a single previously uncharacterized branch that contains S. enterica adapted to multiple mammalian species. All ancient bacterial genomes from prehistoric (agro-)pastoralists fall within a part of this branch that also includes the human-specific S. enterica Paratyphi C, illustrating the evolution of a human pathogen over a period of 5,000 yr. Bacterial genomic comparisons suggest that the earlier ancient strains were not host specific, differed in pathogenic potential and experienced convergent pseudogenization that accompanied their downstream host adaptation. These observations support the concept that the emergence of human-adapted S. enterica is linked to human cultural transformations.

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Sprache(n): eng - English
 Datum: 2020-02-242020-03
 Publikationsstatus: Erschienen
 Seiten: 22
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1038/s41559-020-1106-9
Anderer: shh2524
 Art des Abschluß: -

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Projektname : PALEoRIDER
Grant ID : 771234
Förderprogramm : Horizon 2020 (H2020)
Förderorganisation : European Commission (EC)

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Titel: Nature Ecology & Evolution
  Andere : Nature Ecology and Evolution
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: London : Nature Publishing Group
Seiten: - Band / Heft: 4 (3) Artikelnummer: - Start- / Endseite: 324 - 333 Identifikator: ISSN: 2397-334X
CoNE: https://pure.mpg.de/cone/journals/resource/2397-334X