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Abstract:
The distinction of functional activity between cortical layers in the brain by MRI or MRS requires high spatial and temporal resolution. High spatial resolution can be achieved by increasing the gradient strength or by using the intrinsic volume selectivity of miniature coils, even in conventional animal scanner. In the present work, initial results for highly-localized spectroscopy within seconds are presented, for a phantom metabolite solution and cell cultures in a 14.1T animal scanner using a 2mm-diameter circular coil. The larger signals from the major metabolites in ~1.5µL were detected in 24sec on the phantom solution with an acceptable SNR.
