English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
 DetailsSummary
  Vertical sleeve gastrectomy reduces blood pressure and hypothalamic endoplasmic reticulum stress in mice

McGavigan, A. K., Henseler, Z. M., Garibay, D., Butler, S. D., Jayasinghe, S., Ley, R. E., et al. (2017). Vertical sleeve gastrectomy reduces blood pressure and hypothalamic endoplasmic reticulum stress in mice. DISEASE MODELS & MECHANISMS, 10(3), 235-243. doi:10.1242/dmm.027474.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/21.11116/0000-0002-1308-0 Version Permalink: https://hdl.handle.net/21.11116/0000-0002-1309-F
Genre: Journal Article

Files

show Files

Locators

show
hide
Locator:
http://dmm.biologists.org/content/dmm/early/2017/01/11/dmm.027474.full.pdf (Publisher version)
Description:
-
OA-Status:

Creators

show
hide
 Creators:
McGavigan, Anne K.1, Author
Henseler, Zachariah M.2, 3, Author
Garibay, Darline1, Author
Butler, Scott D.1, Author
Jayasinghe, Sisitha1, Author
Ley, Ruth E.2, 3, Author
Davisson, Robin L.1, 4, Author
Cummings, Bethany P.1, Author
Affiliations:
1Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, ou_persistent22              
2Department of Molecular Biology and Genetics, Cornell University, Ithaca, ou_persistent22              
3Max Planck Institute for Developmental Biology, Max Planck Society, Max-Planck-Ring 5, 72076 Tübingen, DE, ou_2421691              
4Cell and Developmental Biology, Weill Cornell Medical College, New York, ou_persistent22              

Content

show
hide
Free keywords: GASTRIC BYPASS-SURGERY; GLUCAGON-LIKE PEPTIDE-1; GUT MICROBIOTA; OBESE-PATIENTS; MEDICAL-MANAGEMENT; DIABETES-MELLITUS; BARIATRIC SURGERY; MASS-SPECTROMETRY; INSULIN ACTION; HYPERTENSION; Vertical sleeve gastrectomy; Hypertension; ER stress; Mouse model;
 Abstract: Bariatric surgery, such as vertical sleeve gastrectomy (VSG), causes remarkable improvements in cardiometabolic health, including hypertension remission. However, the mechanisms responsible remain undefined and poorly studied. Therefore, we developed and validated the first murine model of VSG that recapitulates the blood pressure-lowering effect of VSG using gold-standard radiotelemetry technology. We used this model to investigate several potential mechanisms, including body mass, brain endoplasmic reticulum (ER) stress signaling and brain inflammatory signaling, which are all critical contributors to the pathogenesis of obesity-associated hypertension. Mice fed on a high-fat diet underwent sham or VSG surgery and radiotelemeter implantation. Sham mice were fed ad libitum or were food restricted to match their body mass to VSG-operated mice to determine the role of body mass in the ability of VSG to lower blood pressure. Blood pressure was then measured in freely moving unstressed mice by radiotelemetry. VSG decreased energy intake, body mass and fat mass. Mean arterial blood pressure (MAP) was reduced in VSG-operated mice compared with both sham-operated groups. VSG-induced reductions in MAP were accompanied by a body mass-independent decrease in hypothalamic ER stress, hypothalamic inflammation and sympathetic nervous system tone. Assessment of gut microbial populations revealed VSG-induced increases in the relative abundance of Gammaproteobacteria and Enterococcus, and decreases in Adlercreutzia. These results suggest that VSG reduces blood pressure, but this is only partly due to the reduction in body weight. VSG-induced reductions in blood pressure may be driven by a decrease in hypothalamic ER stress and inflammatory signaling, and shifts in gut microbial populations.

Details

show
hide
Language(s): eng - English
 Dates: 2017-01-122017-03-01
 Publication Status: Issued
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000395717100004
DOI: 10.1242/dmm.027474
PMID: 28093508
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: DISEASE MODELS & MECHANISMS
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL, CAMBS, ENGLAND : COMPANY OF BIOLOGISTS LTD
Pages: - Volume / Issue: 10 (3) Sequence Number: - Start / End Page: 235 - 243 Identifier: ISSN: 1754-8403