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  CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation

Hsu, J., Huang, H.-T., Lee, C.-T., Choudhuri, A., Wilson, N. K., Abraham, B. J., et al. (2020). CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation. Proceedings of the National Academy of Sciences of the United States of America, 117, 23626-23635.

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https://www.pnas.org/content/117/38/23626 (Publisher version)
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 Creators:
Hsu, Jingmei1, Author
Huang, Hsuan-Ting1, Author
Lee, Chung-Tsai1, Author
Choudhuri, Avik1, Author
Wilson, Nicola K.1, Author
Abraham, Brian J.1, Author
Moignard, Victoria1, Author
Kucinski, Iwo1, Author
Yu, Shuqian1, Author
Hyde, R. Katherine1, Author
Tober, Joanna1, Author
Cai, Xiongwei1, Author
Li, Yan1, Author
Guo, Yalin1, Author
Yang, Song1, Author
Superdock, Michael1, Author
Trompouki, Eirini2, Author              
Calero-Nieto, Fernando J.1, Author
Ghamari, Alireza1, Author
Jiang, Jing1, Author
Gao, Peng1, AuthorGao, Long1, AuthorNguyen, Vy1, AuthorRobertson, Anne L.1, AuthorDurand, Ellen M.1, AuthorKathrein, Katie L.1, AuthorAifantis, Iannis1, AuthorGerber, Scott A.1, AuthorTong, Wei1, AuthorTan, Kai1, AuthorCantor, Alan B.1, AuthorZhou, Yi1, AuthorLiu, P. Paul1, AuthorYoung, Richard A.1, AuthorGöttgens, Berthold1, AuthorSpeck, Nancy A.1, AuthorZon, Leonard I.1, Author more..
Affiliations:
1External Organizations, ou_persistent22              
2Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243641              

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Free keywords: hematopoiesis,, RUNX1, CHD7
 Abstract: Hematopoietic stem and progenitor cell (HSPC) formation and lineage differentiation involve gene expression programs orchestrated by transcription factors and epigenetic regulators. Genetic disruption of the chromatin remodeler chromodomain-helicase-DNA-binding protein 7 (CHD7) expanded phenotypic HSPCs, erythroid, and myeloid lineages in zebrafish and mouse embryos. CHD7 acts to suppress hematopoietic differentiation. Binding motifs for RUNX and other hematopoietic transcription factors are enriched at sites occupied by CHD7, and decreased RUNX1 occupancy correlated with loss of CHD7 localization. CHD7 physically interacts with RUNX1 and suppresses RUNX1-induced expansion of HSPCs during development through modulation of RUNX1 activity. Consequently, the RUNX1:CHD7 axis provides proper timing and function of HSPCs as they emerge during hematopoietic development or mature in adults, representing a distinct and evolutionarily conserved control mechanism to ensure accurate hematopoietic lineage differentiation.

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Language(s): eng - English
 Dates: 2020-09-22
 Publication Status: Published in print
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 Rev. Type: Peer
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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : PNAS
  Other : Proceedings of the National Academy of Sciences of the USA
  Abbreviation : Proc. Natl. Acad. Sci. U. S. A.
Source Genre: Journal
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Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 117 Sequence Number: - Start / End Page: 23626 - 23635 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230