Direct activation of the ion channel TRPA1 by Ca2+.

Zurborg, Sandra; Yurgionas, Brian; Caspani, Ombretta; Heppenstall, Paul A.

doi:10.1038/nn1843

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Direct activation of the ion channel TRPA1 by Ca2+.

Zurborg, S., Yurgionas, B., Caspani, O., & Heppenstall, P. A. (2007). Direct activation of the ion channel TRPA1 by Ca2+. Nature Neuroscience, 10(3), 277-279. doi:10.1038/nn1843.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0012-09B4-7 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-C52D-F

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Zurborg, Sandra¹, Author
Yurgionas, Brian¹, Author
Caspani, Ombretta¹, Author
Heppenstall, Paul A.¹, Author

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1Klinik für Anaesthesiologie und operative Intensivmedizin, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, Hindenburgdamm 30, 12200 Berlin, Germany, ou_persistent22

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Abstract: TRPA1 is an ion channel expressed by nociceptors and activated by irritant compounds such as mustard oil. The endogenous function of TRPA1 has remained unclear, a fact highlighted by ongoing debate over its potential role as a sensor of noxious cold. Here we show that intracellular Ca(2+) activates human TRPA1 via an EF-hand domain and that cold sensitivity occurs indirectly (and nonphysiologically) through increased [Ca(2+)](i) during cooling in heterologous systems.

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Dates: Published Online: 2007-01-28Date issued: 2007-03

Publication Status: Issued

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Identifiers: DOI: 10.1038/nn1843

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Title: Nature Neuroscience

Other : Nat. Neurosci.

Source Genre: Journal

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Pages: - Volume / Issue: 10 (3) Sequence Number: - Start / End Page: 277 - 279 Identifier: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931