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  Spatiotemporally asymmetric excitation supports mammalian retinal motion sensitivity.

Matsumoto, A., Briggman, K. L., & Yonehara, K. (2019). Spatiotemporally asymmetric excitation supports mammalian retinal motion sensitivity. Current Biology, 29(19), 3277-3288. doi:10.1016/j.cub.2019.08.048.

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1-s2.0-S096098221931098X-main.pdf (Publisher version), 6MB
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 Creators:
Matsumoto, Akihiro1, Author
Briggman, Kevin L2, Author
Yonehara, Keisuke1, Author
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1External Organizations, ou_persistent22              
2Department of Computational Neuroethology, Center of Advanced European Studies and Research (caesar), Max Planck Society, ou_3034882              

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 Abstract: The detection of visual motion is a fundamental function of the visual system. How motion speed and direction are computed together at the cellular level, however, remains largely unknown. Here, we suggest a circuit mechanism by which excitatory inputs to direction-selective ganglion cells in the mouse retina become sensitive to the motion speed and direction of image motion. Electrophysiological, imaging, and connectomic analyses provide evidence that the dendrites of ON direction-selective cells receive spatially offset and asymmetrically filtered glutamatergic inputs along motion-preference axis from asymmetrically wired bipolar and amacrine cell types with distinct release dynamics. A computational model shows that, with this spatiotemporal structure, the input amplitude becomes sensitive to speed and direction by a preferred direction enhancement mechanism. Our results highlight the role of an excitatory mechanism in retinal motion computation by which feature selectivity emerges from non-selective inputs. Copyright © 2019 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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Language(s): eng - English
 Dates: 2019-10-072019-09-262019-10-07
 Publication Status: Published in print
 Pages: -
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 Rev. Type: Peer
 Identifiers: ISI: 31564498
DOI: 10.1016/j.cub.2019.08.048
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Title: Current Biology
  Other : Curr Biol
Source Genre: Journal
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Publ. Info: London, UK : Cell Press
Pages: - Volume / Issue: 29 (19) Sequence Number: - Start / End Page: 3277 - 3288 Identifier: ISSN: 0960-9822
CoNE: https://pure.mpg.de/cone/journals/resource/954925579107