English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
 Local TagsRelease HistoryDetailsSummary
  Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases.

Wirth, M., Karaca, S., Wenzel, D., Ho, L., Tishkoff, D., Lombard, D. B., et al. (2013). Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases. Mitochondrion, 13(6), 705-720. doi:10.1016/j.mito.2013.02.002.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000E-FC29-F Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0027-C83D-2
Genre: Journal Article

Files

show Files
hide Files
:
1744051.pdf (Publisher version), 2MB
 
File Permalink:
-
Name:
1744051.pdf
Description:
-
OA-Status:
Visibility:
Restricted (UNKNOWN id 303; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
1744051-Suppl-1.pdf (Supplementary material), 130KB
View   Save
File Permalink:
https://hdl.handle.net/11858/00-001M-0000-0018-DD1C-3
Name:
1744051-Suppl-1.pdf
Description:
-
OA-Status:
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
View
Copyright Date:
-
Copyright Info:
-
License:
-
:
1744051-Suppl-2.pdf (Supplementary material), 209KB
View   Save
File Permalink:
https://hdl.handle.net/11858/00-001M-0000-0018-DD1E-0
Name:
1744051-Suppl-2.pdf
Description:
-
OA-Status:
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
View
Copyright Date:
-
Copyright Info:
-
License:
-
:
1744051-Suppl-3.pdf (Supplementary material), 146KB
View   Save
File Permalink:
https://hdl.handle.net/11858/00-001M-0000-0018-DD24-F
Name:
1744051-Suppl-3.pdf
Description:
-
OA-Status:
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
View
Copyright Date:
-
Copyright Info:
-
License:
-
:
1744051-Suppl-4.pdf (Supplementary material), 891KB
View   Save
File Permalink:
https://hdl.handle.net/11858/00-001M-0000-0018-DD26-B
Name:
1744051-Suppl-4.pdf
Description:
-
OA-Status:
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
View
Copyright Date:
-
Copyright Info:
-
License:
-
:
1744051-Suppl-5.pdf (Supplementary material), 25KB
View   Save
File Permalink:
https://hdl.handle.net/11858/00-001M-0000-0018-DD29-5
Name:
1744051-Suppl-5.pdf
Description:
-
OA-Status:
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
View
Copyright Date:
-
Copyright Info:
-
License:
-
:
1744051-Suppl-6.pdf (Supplementary material), 52KB
View   Save
File Permalink:
https://hdl.handle.net/11858/00-001M-0000-0018-DD2B-1
Name:
1744051-Suppl-6.pdf
Description:
-
OA-Status:
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
View
Copyright Date:
-
Copyright Info:
-
License:
-
:
1744051-Suppl-7.pdf (Supplementary material), 52KB
View   Save
File Permalink:
https://hdl.handle.net/11858/00-001M-0000-0018-DD2D-E
Name:
1744051-Suppl-7.pdf
Description:
-
OA-Status:
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
View
Copyright Date:
-
Copyright Info:
-
License:
-

Creators

show
hide
 Creators:
Wirth, M.1, Author           
Karaca, S.1, Author           
Wenzel, D.2, Author           
Ho, L., Author
Tishkoff, D., Author
Lombard, D. B., Author
Verdin, E., Author
Urlaub, H.3, Author           
Jedrusik-Bode, M.4, Author           
Fischle, W.1, Author           
Affiliations:
1Research Group of Chromatin Biochemistry, MPI for biophysical chemistry, Max Planck Society, ou_578604              
2Facility for Electron Microscopy, MPI for biophysical chemistry, Max Planck Society, ou_578615              
3Research Group of Bioanalytical Mass Spectrometry, MPI for biophysical chemistry, Max Planck Society, ou_578613              
4Department of Genes and Behavior, MPI for biophysical chemistry, Max Planck Society, ou_persistent34              

Content

show
hide
Free keywords: Sirtuins; SIRT4; C. elegans; Biotin-dependent carboxylase; Pyruvate carboxylase; Protein acetylation
 Abstract: The biological and enzymatic function of SIRT4 is largely uncharacterized. We show that the Caenorhabditis elegans SIR-2.2 and SIR-2.3 orthologs of SIRT4 are ubiquitously expressed, also localize to mitochondria and function during oxidative stress. Further, we identified conserved interaction with mitochondrial biotin-dependent carboxylases (PC, PCC, MCCC), key enzymes in anaplerosis and ketone body formation. The carboxylases were found acetylated on multiple lysine residues and detailed analysis of mPC suggested that one of these residues, K748ac, might regulate enzymatic activity. Nevertheless, no changes in mPC acetylation levels and enzymatic activity could be detected upon overexpression or loss of functional SIRT4.

Details

show
hide
Language(s): eng - English
 Dates: 2013-02-212013-11
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.mito.2013.02.002
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Mitochondrion
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 13 (6) Sequence Number: - Start / End Page: 705 - 720 Identifier: -