Thymus development and function

Boehm, Thomas

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Thymus development and function

Boehm, T. (2008). Thymus development and function. Current Opinion in Immunology, 20, 178-184.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-901C-B Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002B-901D-9

Genre: Journal Article

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Creators:
Boehm, Thomas¹, Author

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1Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243647

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Abstract: Thymopoiesis is a complex and highly dynamic process. It involves reciprocal tissue interactions between epithelial cells derived from the endoderm of the anterior foregut and neural crest-derived mesenchyme to form the thymic rudiment. This organ anlage attracts thymocyte progenitors and supports their differentiation and functional maturation into a self-tolerant diverse repertoire of T cells. In recent years, a more detailed picture of the molecular mechanisms determining the formation of the thymic rudiment and those controlling the maturation of the epithelial compartment has emerged and these are briefly summarized here. This review also addresses new experimental approaches toward a better understanding of thymopoiesis and discusses the impact of new animal models.

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Language(s): eng - English

Dates: Date issued: 2008

Publication Status: Issued

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Rev. Type: Peer

Identifiers: eDoc: 400168

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Title: Current Opinion in Immunology

Alternative Title : Curr. Opin. Immunol.

Source Genre: Journal

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Pages: - Volume / Issue: 20 Sequence Number: - Start / End Page: 178 - 184 Identifier: -