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  A near-infrared probe tracks and treats lung tumor initiating cells by targeting HMOX2

Kim, J.-J., Lee, Y.-A., Su, D., Lee, J., Park, S.-J., Kim, B., et al. (2019). A near-infrared probe tracks and treats lung tumor initiating cells by targeting HMOX2. Journal of the American Chemical Society, 141(37), 14673-14686. doi:10.1021/jacs.9b06068.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0007-B10C-4 Version Permalink: https://hdl.handle.net/21.11116/0000-0007-B10D-3
Genre: Journal Article

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 Creators:
Kim, Jong-Jin, Author
Lee, Yong-An, Author
Su, Dongdong, Author
Lee, Jungyeol, Author
Park, Sung-Jin, Author
Kim, Beomsue, Author
Lee, Jia Hui Jane, Author
Liu, Xiao, Author
Kim, Seong Soon, Author
Bae, Myung Ae, Author
Lee, Jun-Seok, Author
Hong, Seong Cheol, Author
Wang, Lu1, Author           
Samanta, Animesh, Author
Kwon, Haw-Young, Author
Choi, So-Young, Author
Kim, Jun-Young, Author
Yu, Young Hyun, Author
Ha, Hyung-Ho, Author
Wang, Zhenxun, Author
Tam, Wai Leong, AuthorLim, Bing, AuthorKang, Nam-Young, AuthorChang, Young-Tae, Author more..
Affiliations:
1Chemical Biology, Max Planck Institute for Medical Research, Max Planck Society, ou_2364732              

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 Abstract: Tumor initiating cells (TIC) are resistant to conventional anticancer therapy and associated with metastasis and relapse in cancer. Although various TIC markers and their antibodies have been proposed, it is limited to the use of antibodies for in vivo imaging or treatment of TIC. In this study, we discovered heme oxygenase 2 (HMOX2) as a novel biomarker for TIC and developed a selective small molecule probe TiNIR (tumor initiating cell probe with near infrared). TiNIR detects and enriches the functionally active TIC in human lung tumors, and through the photoacoustic property, TiNIR also visualizes lung TIC in the patient-derived xenograft (PDX) model. Furthermore, we demonstrate that TiNIR inhibits tumor growth by blocking the function of HMOX2, resulting in significantly increased survival rates of the cancer model mice. The novel therapeutic target HMOX2 and its fluorescent ligand TiNIR will open a new path for the molecular level of lung TIC diagnosis and treatment.

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Language(s): eng - English
 Dates: 2019-06-062019-08-222019-09-18
 Publication Status: Issued
 Pages: 14
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1021/jacs.9b06068
 Degree: -

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Title: Journal of the American Chemical Society
  Other : JACS
  Abbreviation : J. Am. Chem. Soc.
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 141 (37) Sequence Number: - Start / End Page: 14673 - 14686 Identifier: ISSN: 0002-7863
CoNE: https://pure.mpg.de/cone/journals/resource/954925376870