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  Unraveling corticobasal syndrome and alien limb syndrome with structural brain imaging

Albrecht, F., Mueller, K., Ballarini, T., Lampe, L., Diehl-Schmid, J., Fassbender, K., et al. (2019). Unraveling corticobasal syndrome and alien limb syndrome with structural brain imaging. Cortex, 117, 33-40. doi:10.1016/j.cortex.2019.02.015.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-0003-4D20-3 Versions-Permalink: https://hdl.handle.net/21.11116/0000-0004-500A-7
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 Urheber:
Albrecht, Franziska1, Autor           
Mueller, Karsten2, Autor           
Ballarini, Tommaso1, Autor           
Lampe, Leonie1, 3, Autor           
Diehl-Schmid, Janine4, 5, Autor
Fassbender, Klaus4, 6, Autor
Fliessbach, Klaus 4, 7, Autor
Jahn, Holger 4, 8, Autor
Jech, Robert9, Autor
Kassubek, Jan 4, 10, Autor
Kornhuber, Johannes 4, 11, Autor
Landwehrmeyer, Bernhard 10, Autor
Lauer, Martin 4, 12, Autor
Ludolph, Albert C. 10, Autor
Lyros, Epameinondas4, 6, Autor
Prudlo, Johannes 4, 13, Autor
Schneider, Anja 4, 7, Autor
Synofzik, Matthis 4, 14, 15, Autor
Wiltfang, Jens 4, 16, Autor
Danek, Adrian 4, 17, Autor
Otto, Markus4, 10, AutorFTLD-Consortium, Autor              Schroeter, Matthias L.1, 3, 4, Autor            mehr..
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
3Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
4German Consortium for Frontotemporal Lobar Degeneration (FTLD), Germany, ou_persistent22              
5Departments of Psychiatry and Psychotherapy, TU Munich, Germany, ou_persistent22              
6Clinic for Neurology, Saarland University, Saarbrücken, Germany, ou_persistent22              
7Department of Neurodegenerative Disease and Geriatric Psychiatry, University Hospital Bonn, Germany, ou_persistent22              
8Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Germany, ou_persistent22              
9Department of Neurology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ou_persistent22              
10Department of Neurology, Ulm University, Germany, ou_persistent22              
11Department of Psychology and Psychotherapy, Friedrich Alexander University Erlangen, Germany, ou_persistent22              
12Clinic for Psychiatry, Psychosomatic Medicine and Psychotherapy, Julius Maximilian University, Würzburg, Germany, ou_persistent22              
13Department of Neurology, University Medicine Rostock, Germany, ou_persistent22              
14Hertie-Institute for Clinical Brain Research, Eberhard Karls University Tübingen, Germany, ou_persistent22              
15German Center for Neurodegenerative Diseases, Tübingen, Germany, ou_persistent22              
16University Medical Center, Göttingen, Germany, ou_persistent22              
17Department of Neurology, Ludwig Maximilians University Munich, Germany, ou_persistent22              

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Schlagwörter: Alien limb syndrome; Anarchic limb syndrome; Corticobasal syndrome; Diagnosis prediction; Support vector machine
 Zusammenfassung: Alien limb phenomenon is a rare syndrome associated with a feeling of non-belonging and disowning toward one's limb. In contrast, anarchic limb phenomenon leads to involuntary but goal-directed movements. Alien/anarchic limb phenomena are frequent in corticobasal syndrome (CBS), an atypical parkinsonian syndrome characterized by rigidity, akinesia, dystonia, cortical sensory deficit, and apraxia.

The structure–function relationship of alien/anarchic limb was investigated in multi-centric structural magnetic resonance imaging (MRI) data. Whole-group and single-subject comparisons were made in 25 CBS and eight CBS-alien/anarchic limb patients versus controls. Support vector machine was used to see if CBS with and without alien/anarchic limb could be distinguished by structural MRI patterns.

Whole-group comparison of CBS versus controls revealed asymmetric frontotemporal atrophy. CBS with alien/anarchic limb syndrome versus controls showed frontoparietal atrophy including the supplementary motor area contralateral to the side of the affected limb. Exploratory analysis identified frontotemporal regions encompassing the pre-/and postcentral gyrus as compromised in CBS with alien limb syndrome. Classification of CBS patients yielded accuracies of 79%. CBS-alien/anarchic limb syndrome was differentiated from CBS patients with an accuracy of 81%. Predictive differences were found in the cingulate gyrus spreading to frontomedian cortex, postcentral gyrus, and temporoparietoocipital regions.

We present the first MRI-based group analysis on CBS-alien/anarchic limb. Results pave the way for individual clinical syndrome prediction and allow understanding the underlying neurocognitive architecture.

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Sprache(n): eng - English
 Datum: 2018-12-032018-08-102019-02-152019-02-252019-08
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1016/j.cortex.2019.02.015
PMID: 30927559
Anderer: Epub ahead of print
 Art des Abschluß: -

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Projektinformation

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Projektname : German Consortium for Frontotemporal Lobar Degeneration
Grant ID : O1GI1007A
Förderprogramm : -
Förderorganisation : German Federal Ministry of Education and Research (BMBF)
Projektname : -
Grant ID : PDF-IRG-1307
Förderprogramm : -
Förderorganisation : Parkinson's Disease Foundation
Projektname : -
Grant ID : 11362
Förderprogramm : -
Förderorganisation : Michael Fox Foundation
Projektname : -
Grant ID : SCHR 774/5-1
Förderprogramm : -
Förderorganisation : German Research Foundation
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : Else Kröner-Fresenius-Stiftung
Projektname : -
Grant ID : -
Förderprogramm : -
Förderorganisation : International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity (IMPRS NeuroCom)
Projektname : -
Grant ID : 16-13323S
Förderprogramm : -
Förderorganisation : Czech Science Foundation GAČR

Quelle 1

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Titel: Cortex
  Andere : Cortex
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Milan [etc.] : Elsevier Masson SAS
Seiten: - Band / Heft: 117 Artikelnummer: - Start- / Endseite: 33 - 40 Identifikator: ISSN: 0010-9452
CoNE: https://pure.mpg.de/cone/journals/resource/954925393344