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  A Conformational Change in the α‐subunit of Coatomer Induced by Ligand Binding to γ‐COP Revealed by Single‐pair FRET

Langer, J. D., Roth, C. M., Béthune, J., Stoops, E. H., Brügger, B., Herten, D.-P., et al. (2008). A Conformational Change in the α‐subunit of Coatomer Induced by Ligand Binding to γ‐COP Revealed by Single‐pair FRET. Traffic, 9(4), 597-607. doi:10.1111/j.1600-0854.2007.00697.x.

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 Urheber:
Langer, Julian David1, Autor           
Roth, Christian M.2, Autor
Béthune, Julien 1, Autor
Stoops, Emily H.1, Autor
Brügger, Britta1, Autor
Herten, Dirk-Peter2, Autor
Wieland, Felix T.1, Autor
Affiliations:
1Heidelberg University Biochemistry Center, Heidelberg University, 69120 Heidelberg, Germany, ou_persistent22              
2CellNetworks/BIOQUANT, Heidelberg University, Im Neuenheimer Feld 267/BQ 0007, 69120 Heidelberg, Germany, ou_persistent22              

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Schlagwörter: COPI; coatomer; fluorescence resonance energy transfer; p24 proteins; single‐molecule spectroscopy
 Zusammenfassung: Formation of transport vesicles involves polymerization of cytoplasmic coat proteins (COP). In COPI vesicle biogenesis, the heptameric complex coatomer is recruited to donor membranes by the interaction of multiple coatomer subunits with the budding machinery. Specific binding to the trunk domain of γ‐COP by the Golgi membrane protein p23 induces a conformational change that causes polymerization of the complex. Using single‐pair fluorescence resonance energy transfer, we find that this conformational change takes place in individual coatomer complexes, independent of each other, and that the conformational rearrangement induced in γ‐COP is transmitted within the complex to its α‐subunit. We suggest that capture of membrane protein machinery triggers cage formation in the COPI system.

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Sprache(n): eng - English
 Datum: 2007-05-042007-12-202007-12-252008-04-01
 Publikationsstatus: Erschienen
 Seiten: 11
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1111/j.1600-0854.2007.00697.x
PMID: 18182008
 Art des Abschluß: -

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Titel: Traffic
  Kurztitel : tra
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Oxford, UK : Wiley-Blackwell
Seiten: - Band / Heft: 9 (4) Artikelnummer: - Start- / Endseite: 597 - 607 Identifikator: ISSN: 1600-0854
CoNE: https://pure.mpg.de/cone/journals/resource/1600-0854