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  Physical phenotype of blood cells is altered in COVID-19

Kubánková, M., Hohberger, B., Hoffmanns, J., Fürst, J., Herrmann, M., Guck, J., et al. (2021). Physical phenotype of blood cells is altered in COVID-19. bioRxiv:2021.02.12.429482.

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bioRxiv 2021 Kubankova.pdf (Preprint), 2MB
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bioRxiv 2021 Kubankova.pdf
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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

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Kubánková, Markéta1, Autor           
Hohberger, Bettina2, Autor
Hoffmanns, Jakob2, Autor
Fürst, Julia2, Autor
Herrmann, Martin2, 3, Autor
Guck, Jochen1, 2, 4, Autor           
Kräter, Martin1, Autor           
Affiliations:
1Guck Division, Max Planck Institute for the Science of Light, Max Planck Society, ou_3164416              
2Friedrich-Alexander-Universität Erlangen-Nürnberg, ou_persistent22              
3external, ou_persistent22              
4Max-Planck-Zentrum für Physik und Medizin, Max Planck Institute for the Science of Light, Max Planck Society, ou_3164414              

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 Zusammenfassung: Clinical syndrome coronavirus disease 2019 (COVID-19) induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by rapid spreading and high mortality worldwide. While the pathology is not yet fully understood, hyper-inflammatory response and coagulation disorders leading to congestions of microvessels are considered to be key drivers of the still increasing death toll. Until now, physical changes of blood cells have not been considered to play a role in COVID-19 related vascular occlusion and organ damage. Here we report an evaluation of multiple physical parameters including the mechanical features of five frequent blood cell types, namely erythrocytes, lymphocytes, monocytes, neutrophils, and eosinophils. More than 4 million blood cells of 17 COVID-19 patients at different levels of severity, 24 volunteers free from infectious or inflammatory diseases, and 14 recovered COVID-19 patients were analyzed. We found significant changes in erythrocyte deformability, lymphocyte stiffness, monocyte size, and neutrophil size and deformability. While some of these changes recovered to normal values after hospitalization, others persisted for months after hospital discharge, evidencing the long-term imprint of COVID-19 on the body.

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Sprache(n): eng - English
 Datum: 2021-02-12
 Publikationsstatus: Online veröffentlicht
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 Identifikatoren: arXiv: 2021.02.12.429482
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Titel: bioRxiv:2021.02.12.429482
Genre der Quelle: Kommentar
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