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  Neuroplasticity of language in left‐hemisphere stroke: Evidence linking subsecond electrophysiology and structural connections

Piai, V., Meyer, L., Dronkers, N., & Robert T., K. (2017). Neuroplasticity of language in left‐hemisphere stroke: Evidence linking subsecond electrophysiology and structural connections. Human Brain Mapping, 38(6), 3151-3162. doi:10.1002/hbm.23581.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0004-5B1D-7 Version Permalink: https://hdl.handle.net/21.11116/0000-0004-DD58-1
Genre: Journal Article

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 Creators:
Piai, Vitória 1, 2, 3, 4, Author
Meyer, Lars5, Author           
Dronkers, Nina4, 6, 7, Author
Robert T., Knight3, Author
Affiliations:
1Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
2Department of Medical Psychology, Radboud University Medical Center, Nijmegen, the Netherlands, ou_persistent22              
3Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA, ou_persistent22              
4Center for Aphasia and Related Disorders, Veterans Affairs Northern California Health Care System, Martinez, CA, USA, ou_persistent22              
5Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634551              
6Department of Neurology, University of California Davis, CA, USA, ou_persistent22              
7Neurolinguistics Laboratory, National Research University Higher School of Economics, Moscow, Russia, ou_persistent22              

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Free keywords: Context; Disconnection; Neuroplasticity; Oscillations; Production; Splenium; Tapetum
 Abstract: The understanding of neuroplasticity following stroke is predominantly based on neuroimaging measures that cannot address the subsecond neurodynamics of impaired language processing. We combined behavioral and electrophysiological measures and structural‐connectivity estimates to characterize neuroplasticity underlying successful compensation of language abilities after left‐hemispheric stroke. We recorded the electroencephalogram from patients with stroke lesions to the left temporal lobe and from matched controls during context‐driven word retrieval. Participants heard lead‐in sentences that either constrained the final word (“He locked the door with the”) or not (“She walked in here with the”). The last word was shown as a picture to be named. Individual‐participant analyses were conducted, focusing on oscillatory power as a subsecond indicator of a brain region's functional neurophysiological computations. All participants named pictures faster following constrained than unconstrained sentences, except for two patients, who had extensive damage to the left temporal lobe. Left‐lateralized alpha–beta oscillatory power decreased in controls pre‐picture presentation for constrained relative to unconstrained contexts. In patients, the alpha–beta power decreases were observed with the same time course as in controls but were lateralized to the intact right hemisphere. The right lateralization depended on the probability of white‐matter connections between the bilateral temporal lobes. The two patients who performed poorly behaviorally showed no alpha–beta power decreases. Our findings suggest that incorporating direct measures of neural activity into investigations of neuroplasticity can provide important neural markers to help predict language recovery, assess the progress of neurorehabilitation, and delineate targets for therapeutic neuromodulation.

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Language(s): eng - English
 Dates: 2017-03-082016-11-152017-03-112017-03-272017-06
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/hbm.23581
PMID: 28345282
PMC: PMC5610921
Other: Epub 2017
 Degree: -

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Project name : -
Grant ID : 446‐13‐009
Funding program : -
Funding organization : Netherlands Organization for Scientific Research (NWO)
Project name : -
Grant ID : NINDS R37 NS21135
Funding program : -
Funding organization : National Institutes of Health (NIH)
Project name : -
Grant ID : CX000254
Funding program : -
Funding organization : US Department of Veterans Affairs Clinical Sciences Research and Development
Project name : -
Grant ID : -
Funding program : Basic Research Program
Funding organization : National Research University Higher School of Economics
Project name : -
Grant ID : -
Funding program : Russian Academic Excellence Project 5–100
Funding organization : Ministry of Science and Higher Education of the Russian Federation

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Title: Human Brain Mapping
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 38 (6) Sequence Number: - Start / End Page: 3151 - 3162 Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686