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  Sequential stimulation of rat cerebellar granular layer in vivo: Further evidence of a "tidal-wave" timing mechanism in the cerebellum

Heck, D., Sultan, F., & Braitenberg, V. (2001). Sequential stimulation of rat cerebellar granular layer in vivo: Further evidence of a "tidal-wave" timing mechanism in the cerebellum. Neurocomputing, 38-40, 641-646. doi:10.1016/S0925-2312(01)00421-0.

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Heck, D, Author           
Sultan, F, Author           
Braitenberg, V1, 2, Author           
Affiliations:
1Former Department Structure and Function of Natural Nerve-Net, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497803              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Here we present evidence that the cerebellar cortex in vivo specifically responds to sequential input to the granular layer, the main input site of the
cerebellar cortex. Ordered sequences of electrical stimuli were delivered through an array of stimulating electrodes in such a way, that an apparent movement
of the stimulus was produced. The parallel fiber population responses to sequential stimuli ‘moving‘ at 7 different velocities (0.1-0.7m/s) and in two different
directions (towards and away from the recording site) were measured extracellularly in the molecular layer. Population responses were maximal when the
stimulus moved towards the recording site at a velocity close to the conduction velocity of parallel fibers. Responses were significantly reduced when the
stimulus velocity was higher or lower. We conclude that the characteristic geometrical arrangement of parallel fibers enables the cerebellum to specifically
detect precise spatio- temporal activity patterns in the messy fiber system. These findings confirm earlier observations made in vitro and shed new light on the
functional interpretation of cerebellar anatomy. Together with recent findings suggesting that precise spatio-temporal activity patterns play a key role in
information processing in the neocortex, the results reported here are particularly important concerning the information exchange between the strongly
interconnected cerebellum and neocortex. (C) 2001 Elsevier Science B.V. All rights reserved.

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 Dates: 2001-06
 Publication Status: Issued
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 Rev. Type: -
 Identifiers: DOI: 10.1016/S0925-2312(01)00421-0
BibTex Citekey: 39
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Title: Neurocomputing
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 38-40 Sequence Number: - Start / End Page: 641 - 646 Identifier: ISSN: 0925-2312
CoNE: https://pure.mpg.de/cone/journals/resource/954925566733