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  Association of estradiol and visceral fat with structural brain networks and memory performance in adults

Zsido, R., Heinrich, M., Slavich, G. M., Beyer, F., Kharabian, S., Kratzsch, J., Raschpichler, M., Mueller, K., Scharrer, U., Löffler, M., Schroeter, M. L., Stumvoll, M., Villringer, A., Witte, A. V., & Sacher, J. (2019). Association of estradiol and visceral fat with structural brain networks and memory performance in adults. JAMA Network Open, 2(6):. doi:10.1001/jamanetworkopen.2019.6126.

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アイテムのパーマリンク: https://hdl.handle.net/21.11116/0000-0003-F9A7-8 版のパーマリンク: https://hdl.handle.net/21.11116/0000-0005-0EF5-8
資料種別: 学術論文

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Zsido_2019.pdf (出版社版), 3MB
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https://hdl.handle.net/21.11116/0000-0003-F9A9-6
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Zsido_2019.pdf
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application/pdf / [MD5]
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作成者

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 作成者:
Zsido, Rachel1, 2, 著者           
Heinrich, Matthias1, 2, 著者           
Slavich, George M.3, 著者
Beyer, Frauke1, 4, 著者           
Kharabian, Shahrzad1, 著者           
Kratzsch, Jürgen5, 著者
Raschpichler, Matthias6, 7, 著者
Mueller, Karsten8, 著者           
Scharrer, Ulrike1, 2, 9, 著者
Löffler, Markus10, 11, 著者
Schroeter, Matthias L.1, 9, 11, 著者           
Stumvoll, Michael4, 7, 著者
Villringer, Arno1, 9, 11, 著者           
Witte, A. Veronica1, 4, 著者           
Sacher, Julia1, 2, 9, 著者           
所属:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Emotion Neuroimaging Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_persistent22              
3Cousins Center for Psychoneuroimmunology, Department of Psychiatry, University of California, Los Angeles, CA, USA, ou_persistent22              
4Collaborative Research Center Obesity Mechanisms, Institute of Biochemistry, University of Leipzig, Germany, ou_persistent22              
5Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
6Heart Center, Helios Hospital, University of Leipzig, Germany, ou_persistent22              
7Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
8Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
9Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
10Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Germany, ou_persistent22              
11Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              

内容説明

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 要旨: Importance Changes in estradiol during aging are associated with increased dementia risk. It remains unclear how estradiol supports cognitive health and whether risk factors, such as midlife obesity, are exacerbated by estrogen loss.

Objectives To assess whether visceral adipose tissue (VAT) moderates the association between age and brain network structure and to investigate whether estradiol moderates the association between VAT and brain network structure.

Design, Setting, and Participants Cross-sectional study of data from 974 cognitively healthy adults in Germany who participated in the Health Study of the Leipzig Research Centre for Civilization Diseases, a previously described population-based cohort study. Two moderation analyses were performed, including VAT as the moderator variable between age and brain network structure and estradiol as the moderator variable between VAT and brain network structure. The study was conducted from August 1, 2011, to November 23, 2014. Analyses were conducted from August 2017 to September 2018

資料詳細

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言語: eng - English
 日付: 2019-05-032019-06-21
 出版の状態: オンラインで出版済み
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子（DOI, ISBNなど）: DOI: 10.1001/jamanetworkopen.2019.6126
PMID: 31225892
PMC: PMC6593958
 学位: -

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Project information

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Project name : -
Grant ID : -
Funding program : The Branco Weiss Fellowship – Society in Science
Funding organization : ETH Zurich
Project name : -
Grant ID : 25032
Funding program : Young Investigator Grant
Funding organization : Brain & Behavior Research Foundation
Project name : -
Grant ID : 713-241202 ; 14505/2470 ; 14575/2470
Funding program : -
Funding organization : LIFE – Leipzig Research Center for Civilization Diseases, University of Leipzig
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Funding organization : European Union (EU)
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Funding program : European Regional Development Fund
Funding organization : European Commission (EC)
Project name : -
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Funding organization : Free State of Saxony
Project name : -
Grant ID : -
Funding program : Minerva Research Group Grant
Funding organization : Max Planck Society
Project name : Obesity Mechanisms / SFB 1052
Grant ID : -
Funding program : -
Funding organization : Deutsche Forschungsgemeinschaft (DFG)

出版物 1

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出版物名: JAMA Network Open
種別: 学術雑誌
 著者・編者:
所属:
出版社, 出版地: Chicago, IL : American Medical Association
ページ: - 巻号: 2 (6) 通巻号: e196126 開始・終了ページ: - 識別子（ISBN, ISSN, DOIなど）: ISSN: 2574-3805
CoNE: https://pure.mpg.de/cone/journals/resource/2574-3805