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  Differential c-Fos induction by different NMDA receptor antagonists with antidepressant efficacy: potential clinical implications

Inta, D., Trusel, M., Riva, M. A., Sprengel, R., & Gass, P. (2009). Differential c-Fos induction by different NMDA receptor antagonists with antidepressant efficacy: potential clinical implications. International Journal of Neuropsychopharmacology, 12(8), 1133-1136. doi:10.1017/S1461145709990319.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-115F-9 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-1160-3
Genre: Journal Article
Alternative Title : Differential c-Fos induction by different NMDA receptor antagonists with antidepressant efficacy: potential clinical implications

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IntJNeuropsychopharmacol_12_2009_1133.pdf (Any fulltext), 151KB
 
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http://dx.doi.org/10.1017/S1461145709990319 (Any fulltext)
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 Creators:
Inta, Dragos, Author
Trusel, Massimo, Author
Riva, Marco Andrea, Author
Sprengel, Rolf1, Author           
Gass, Peter, Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Free keywords: c-Fos; depression; glutamate receptors; NR2B; mice
 Abstract: Preclinical and clinical studies have shown that N-methyl-D-aspartate (NMDA) receptor antagonists can exert antidepressant effects. Thus, a single intravenous injection of ketamine, a non-competitive NMDA receptor antagonists, has been recently demonstrated to produce a rapid and relatively sustained antidepressant effect in patients. Therefore, the role of NMDA receptors and their signalling pathways for pathophysiology and therapy of depression are under intense research.

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Language(s): eng - English
 Dates: 2009-06-182009-05-042009-06-192009-07-292009-09-01
 Publication Status: Issued
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 664674
DOI: 10.1017/S1461145709990319
URI: http://www.ncbi.nlm.nih.gov/pubmed/19638253
Other: 7500
 Degree: -

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Title: International Journal of Neuropsychopharmacology
  Other : Int. J. Neuropsychopharmacol.
Source Genre: Journal
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Publ. Info: Cambridge : Cambridge University Press
Pages: - Volume / Issue: 12 (8) Sequence Number: - Start / End Page: 1133 - 1136 Identifier: ISSN: 1461-1457
CoNE: https://pure.mpg.de/cone/journals/resource/963017835281