Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

 
 
DownloadE-Mail
  Exenatide-induced reduction in energy intake is associated with increase in hypothalamic connectivity

Schlögl, H., Kabisch, S., Horstmann, A., Lohmann, G., Mueller, K., Lepsien, J., et al. (2013). Exenatide-induced reduction in energy intake is associated with increase in hypothalamic connectivity. Diabetes Care, 36(7), 1933-1940. doi:10.2337/dc12-1925.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Externe Referenzen

einblenden:
ausblenden:
externe Referenz:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687323/ (beliebiger Volltext)
Beschreibung:
-
OA-Status:

Urheber

einblenden:
ausblenden:
 Urheber:
Schlögl, Haiko1, Autor           
Kabisch, Stefan1, Autor           
Horstmann, Annette2, 3, Autor           
Lohmann, Gabriele4, Autor           
Mueller, Karsten5, Autor           
Lepsien, Jöran5, Autor           
Busse, Franziska P.1, Autor           
Kratzsch, Jürgen6, Autor
Pleger, Burkhard2, 7, Autor           
Villringer, Arno2, 7, Autor           
Stumvoll, Michael1, 3, Autor
Affiliations:
1Faculty of Medicine, University of Leipzig, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
4Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634550              
5Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
6Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
7Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: OBJECTIVE Glucagon-like peptide-1 receptor agonists such as exenatide are known to influence neural activity in the hypothalamus of animals and to reduce energy intake. In humans, however, significant weight loss has been observed in only a subgroup of patients. Why only some individuals respond with weight loss and others do not remains unclear. In this functional magnetic resonance imaging (fMRI) study, we investigated differences in hypothalamic connectivity between "responders" (reduction in energy intake after exenatide infusion) and "nonresponders." RESEARCH DESIGN AND METHODS We performed a randomized, double-blinded, placebo-controlled, cross-over fMRI study with intravenous administration of exenatide in obese male volunteers. During brain scanning with continuous exenatide or placebo administration, participants rated food and nonfood images. After each scanning session, energy intake was measured using an ad libitum buffet. Functional hypothalamic connectivity was assessed by eigenvector centrality mapping, a measure of connectedness throughout the brain. RESULTS Responders showed significantly higher connectedness of the hypothalamus, which was specific for the food pictures condition, in the exenatide condition compared with placebo. Nonresponders did not show any significant exenatide-induced changes in hypothalamic connectedness. CONCLUSIONS Our results demonstrate a central hypothalamic effect of peripherally administered exenatide that occurred only in the group that showed an exenatide-dependent anorexigenic effect. These findings indicate that the hypothalamic response seems to be the crucial factor for the effect of exenatide on energy intake.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2013-03-052013-07
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.2337/dc12-1925
PMID: 23462665
PMC: PMC3687323
Anderer: Epub 2013
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Diabetes Care
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Alexandria, VA : American Diabetes Association
Seiten: - Band / Heft: 36 (7) Artikelnummer: - Start- / Endseite: 1933 - 1940 Identifikator: ISSN: 0149-5992
CoNE: https://pure.mpg.de/cone/journals/resource/110978984565249