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  Synthetic strategies for preparation of cyclen-based MRI contrast agents

Cakić, N., Gündüz, S., Rengarasu, R., & Angelovski, G. (2015). Synthetic strategies for preparation of cyclen-based MRI contrast agents. Tetrahedron Letters, 56(6), 759-765. doi:10.1016/j.tetlet.2014.12.087.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002A-4774-E Version Permalink: https://hdl.handle.net/21.11116/0000-0003-8A18-7
Genre: Journal Article

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http://www.sciencedirect.com/science/article/pii/S0040403914021534 (Publisher version)
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 Creators:
Cakić, N1, 2, Author           
Gündüz, S1, Author           
Rengarasu, R1, Author           
Angelovski, G1, 3, Author           
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497796              
3Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528691              

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 Abstract: Cyclen-based macrocyclic ligands have an essential role in the development of contrast agents for magnetic resonance imaging (MRI). A prevailing need for preparation of multifunctional probes triggered a number of attempts to synthesize and derivatise ligands which efficiently chelate lanthanide ions and have advantageous MRI properties. This digest article summarizes the most common synthetic approaches for the preparation of macrocyclic ligands based on cyclen depending on the desired application.

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 Dates: 2015-02
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.tetlet.2014.12.087
BibTex Citekey: CakiGRA2014
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Title: Tetrahedron Letters
  Other : Tetrahedron Lett.
Source Genre: Journal
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Publ. Info: Oxford : Pergamon
Pages: - Volume / Issue: 56 (6) Sequence Number: - Start / End Page: 759 - 765 Identifier: ISSN: 0040-4039
CoNE: https://pure.mpg.de/cone/journals/resource/954925448772