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  Nitric oxide synthase (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity.

Dreyer, J., Schleicher, M., Tappe-Theodor, A., Schilling, K., Kuner, T., Kusumawidijaja, G., et al. (2004). Nitric oxide synthase (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience, 24(46), 10454-10465. doi:10.1523/JNEUROSCI.2265-04.2004.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-002A-15E7-1 Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-002A-15E8-0
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Alternativer Titel : Nitric oxide synthase (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity.

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 Urheber:
Dreyer, Jacqueline, Autor
Schleicher, Michael, Autor
Tappe-Theodor, Anke, Autor
Schilling, Kirstin, Autor
Kuner, Thomas1, 2, Autor           
Kusumawidijaja, Grace, Autor
Müller-Esterl, Werner, Autor
Oess, Stefanie, Autor
Kuner, Rohini, Autor
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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Schlagwörter: nitric oxide; synaptic spines; hippocampal neurons; protein-protein interactions; seizures; inflammatory pain
 Zusammenfassung: Mechanisms governing the activity of neuronal nitric oxide synthase (nNOS), the major source of nitric oxide (NO) in the nervous system, are not completely understood. We report here a protein-protein interaction between nNOS and NOSIP (nitric oxide synthase-interacting protein) in rat brain in vivo. NOSIP and nNOS are concentrated in neuronal synapses and demonstrate significant colocalization in various regions of the central and peripheral nervous systems. NOSIP produces a significant reduction in nNOS activity in a neuroepithelioma cell line stably expressing nNOS. Furthermore, overexpression of NOSIP in cultured primary neurons reduces the availability of nNOS in terminal dendrites. These results thus suggest that the interaction between NOSIP and nNOS is functionally involved in endogenous mechanisms regulating NO synthesis. Furthermore, we found that the subcellular distribution and expression levels of NOSIP are dynamically regulated by neuronal activity in vitro as well as in vivo, suggesting that NOSIP may contribute to a mechanism via which neuronal activity regulates the synaptic availability and activity of nNOS.

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Sprache(n): eng - English
 Datum: 2004-10-072004-06-092004-10-072004-11-17
 Publikationsstatus: Erschienen
 Seiten: 12
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 665617
DOI: 10.1523/JNEUROSCI.2265-04.2004
URI: http://www.ncbi.nlm.nih.gov/pubmed/15548660
URI: http://www.jneurosci.org/content/24/46/10454
URI: http://www.jneurosci.org/content/24/46/10454.full
Anderer: 6347
 Art des Abschluß: -

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Titel: The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
  Andere : J. Neurosci.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Baltimore, MD : The Society
Seiten: - Band / Heft: 24 (46) Artikelnummer: - Start- / Endseite: 10454 - 10465 Identifikator: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1